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Identifier
NSP2

Gene
ORF1ab
Protein name
Replicase polyprotein 1ab – Non-structural protein 2
Localization
cytoplasm
Uniprot
P0DTD1
Description

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses. (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

AYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGG
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

Zoom:

Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

Zoom:

Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
FKBP1523307 / Q5T1M512.8337.110.3852.33151.340
SPATS2L26010 / Q9NUQ69.338.570.010.330.30.3
COTL123406 / Q140199.081.690.014.080.760.23
RPL7A6130 / P6242470.820.010.50.060.26
RAP1GDS15910 / P523066.5Infinity0---
ATP2A2488 / P166155.170.150.014.670.130.16
SLC1A56510 / Q157583.50.72030.610
PAIP110605 / Q9H07438.21012.740.1
PPP1CC5501 / P3687332.202.51.830.05
RPL296159 / P479142.54.1901.52.520.07
ASRGL180150 / Q7L2662.56.840---
PHACTR29749 / O751672.5Infinity0---
ARHGAP1392 / Q079602.420.340.4219.422.730
DNAJB1479982 / Q8TBM820.95010.480.1
NARS14677 / O4377621.73010.870.1
SNX1229934 / Q9UMY42Infinity0---
RPL149045 / P509140.670.40.226.173.660
TOGARAM123116 / Q9Y4F4---4.2523.260.01
AKT1207 / P31749---2Infinity0