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Identifier
NSP12

Gene
ORF1ab
Protein name
Replicase polyprotein 1ab – RNA-directed RNA polymerase
Localization
cytoplasm
Uniprot
P0DTD1
Description

Responsible for replication and transcription of the viral RNA genome. (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

SADAQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQ
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

Zoom:

Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

Zoom:

Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
AKR1C11645 / Q0482843.470.047.56.50
TTC47268 / O958011.50.770.0731.540
MYCBP223077 / O7559210.220.1102.210
RPL18A6142 / Q02543---2.50.40
DHCR71717 / Q9UBM7---20.320
DMXL11657 / Q9Y485---60650