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Identifier
NSP13

Gene
ORF1ab
Protein name
Replicase polyprotein 1ab – Helicase
Localization
cytoplasm
Uniprot
P0DTD1
Description

Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium. (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

AVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQ
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

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Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

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Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
RPL36122 / P3902364.51.7047.51.250.07
GAPDH2597 / P0440654.171.98029.171.070.51
CLTC1213 / Q0061041.081.18026.580.760
RPL66128 / Q0287837.422.16025.421.470.3
RAN5901 / P6282636.832.5016.831.140.44
SLC25A4291 / P1223534.832.17028.331.770
RPL156138 / P61313282.480141.240.2
FSCN16624 / Q1665824.082.11016.081.410
PTGR122949 / Q1491422.833.33014.332.090
DDX219188 / Q9NR3021.51.13020.51.080
MCM54174 / P3399220.51.6809.50.780
RPS36188 / P2339620.331.33015.3310
RPN26185 / P0484419.421.65016.421.390
HACD351495 / Q9P03518.751.9017.251.750
RPL286158 / P4677916.832.660.016.831.080.24
ATP2A2488 / P1661516.670.49013.670.40
MBOAT779143 / Q96N6615.831.68010.331.10
RAB1A5861 / P6282015.331.550.0113.331.350.01
RPL76129 / P1812415.252.42013.252.10
TECR9524 / Q9NZ0114.832.38010.831.740
COTL123406 / Q1401914.082.71010.582.040.01
AP2M11173 / Q96CW1141.6408.510
RCC255920 / Q9P258141.5606.50.730
RAB1B81876 / Q9H0U4141.73013.51.670
RAB3511021 / Q15286142.150101.540.01
PHLDB290102 / Q86SQ013.678.530.2243.6727.240
RPL7A6130 / P6242413.51.63060.720.02
RPS276232 / P4267713.251.8011.251.530.01
NAT1055226 / Q9H0A012.921.290.0111.421.140.03
PSMB55693 / P2807412.52.45061.180
RPS116205 / P6228012.331.81010.331.510.01
TRAM123471 / Q15629122.2505.51.030
RPS27L51065 / Q71UM5122.4805.51.130.04
RPL13A23521 / P4042911.831.8404.830.750.2
PAFAH1B15048 / P4303411.671.27010.171.110
TCP16950 / P1798711.671.9704.670.790.22
EIF4A11973 / P6084211.582.0705.080.910.2
RPL216144 / P4677811.52.41061.260
RPS96203 / P4678111.333.1207.332.020
PRMT13276 / Q99873111.8807.51.280
DDX39B7919 / Q13838111.5908.51.230
RPL266154 / P6125410.921.6506.921.040.01
RPL276155 / P6135310.422.1107.421.50.01
CAD790 / P277089.830.9906.330.630
WDR19948 / O750839.751.1707.250.870.01
EIF2S31968 / P410919.581.10.1615.081.730
RPL18A6142 / Q025439.51.6040.680
ACOT711332 / O001549.51.8011.52.170
DARS11615 / P148689.331.3506.330.910
RPS66194 / P627538.832.1702.330.570.02
FADS29415 / O958648.671.10.016.170.780.16
RPN16184 / P048438.51.105.50.710
FAM83H286077 / Q6ZRV28.58.190.4936.535.150.01
RAB1451552 / P611068.51.7305.51.120
MEIOC284071 / A2RUB18.252.080.4124.256.110
RPL27A6157 / P467768.172.0605.671.430
MGST14257 / P1062081.710.015.51.180.03
SNRPD16632 / P6231482.35051.470
TMEM3355161 / P5708881.8107.51.70
RAB2A5862 / P6101982.3803.51.040
RAB8A4218 / P6100681.67081.670
RPL36AL6166 / Q969Q083.22041.610
RPL136137 / P263737.671.7702.670.620.19
CES11066 / P231417.580.707.080.650.02
SEC23A10484 / Q154367.51.99041.060
RAB135872 / P511537.52.50620
BUB39184 / O4368472.01030.860
DHCR71717 / Q9UBM771.14081.310
SMU155234 / Q2TAY771.4604.50.940
SLC1A56510 / Q1575871.47061.260
RAB8B51762 / Q9293071.7307.51.860
EIF2S11965 / P051986.51.15050.880
TM9SF49777 / Q925446.51.95051.50
LTA4H4048 / P099606.55.83032.690
ARF4378 / P180856.51.1805.510
COPB29276 / P356066.330.7101.830.210.16
RPL186141 / Q070206.171.980.011.670.540.2
PRMT510419 / O1474461.7204.51.290
NCEH157552 / Q6PIU261.62020.540.05
CDC42998 / P6095361.540112.830
ARPC1B10095 / O151435.831.060.016.831.240.01
ALDOA226 / P040755.751.30.014.250.960.02
SPECC1L23384 / Q69YQ05.7542.710.1613.75102.140
SRC6714 / P129315.750.860.013.250.490.02
STOM2040 / P271055.670.680.016.670.80
BOP123246 / Q141375.581.80.012.580.830.21
RPL306156 / P628885.51.6603.51.060
RPL35A6165 / P180775.51.75061.910
DERL179139 / Q9BUN85.171.750.015.171.750.01
RPL86132 / P6291751.8201.50.550.07
RPS246229 / P6284751.8305.52.010
DYNC1I21781 / Q1340951.3702.50.680
RPS4Y16192 / P2209052.9201.50.880.07
ACSL32181 / O9557350.36010.070.1
TOMM4010452 / O960084.832.810.011.330.770.17
SLC16A16566 / P539854.51.802.510
ERC123085 / Q8IUD24.520.4964.528.670
FADS13992 / O604274.51.1401.50.380.07
PLRG15356 / O436604.52.25010.50.1
LCLAT1253558 / Q6UWP74.51.18010.260.1
PRPF1927339 / Q9UMS44.52.29010.510.1
RPL96133 / P3296941.11051.380
RPL239349 / P6282941.3203.51.160
RAB7A7879 / P5114941.301.50.490.07
PIGU128869 / Q9H49041.1401.50.430.07
STT3A3703 / P4697740.6803.50.590
MAGT184061 / Q9H0U341.3501.50.510.07
CERS229956 / Q96G2341.530---
NCOA48031 / Q137723.921.490.3423.428.880
TMEM205374882 / Q6UW683.51.26041.430
ARL1400 / P406163.51.7802.51.270
ABCG29429 / Q9UNQ03.50.79020.450
TRIP119321 / Q156433.50.060.42230.380
MGST34259 / O148803.52.1402.51.530
CDIPT10423 / O147353.54.1402.52.950
GHITM27069 / Q9H3K23.51.9010.540.1
ARL8B55207 / Q9NVJ23.51.64031.410
TM9SF356889 / Q9HD453.50.803.50.80
WDR1857418 / Q9BV383.51.14020.650
SOGA1140710 / O949643.58.270.176.515.360.01
PCNT5116 / O956133.518.20315.60
TMX251075 / Q9Y3203.50.7201.50.310.07
RPL37A6168 / P615133.53.370---
SERPINH1871 / P504543.50.750---
ADAM98754 / Q134433.50.540---
VDAC37419 / Q9Y2773.51.610---
CCP1109738 / O433033.251.240.4329.2511.180
MYADM91663 / Q96S9731.3041.730
SDHA6389 / P3104031.0403.51.210
MPDU19526 / O75352320320
DDOST1650 / P3965631.37020.910
PHLDB123187 / Q86UU13120.199.5380
SLC7A1123657 / Q9UPY530.7102.50.590
RPL126136 / P3005031.860---
TM9SF29375 / Q9980531.040---
VPS26A9559 / O7543632.360---
TFRC7037 / P0278630.50---
PPP6R122870 / Q9UPN72.580.90.4319.586.80
FXR29513 / P511162.580.820.216.582.090.01
PPIB5479 / P232842.50.66010.270.1
ABCC14363 / P335272.50.120.053.50.170
STT3B201595 / Q8TCJ22.50.18010.070.1
ITGA33675 / P260062.50.440---
DPP991039 / Q86TI22.50.670---
RPS4X6191 / P627012.51.60---
DYNLL18655 / P631672.52.10---
AP3M126985 / Q9Y2T22.53.820---
OFD18481 / O756652.331.250.3212.336.640.01
KIDINS22057498 / Q9ULH02.331.170.3523.8311.920
SLC39A1423516 / Q1504320.8702.51.090
RAC15879 / P6300020.640.0530.960
RFT191869 / Q96AA321.28021.280
CLN654982 / Q9NWW5240120.1
CYBA1535 / P1349821.860---
AGTRAP57085 / Q6RW1323.350---
IMPA13612 / P2921822.040---
GPAA18733 / O4329222.360---
SLC35F654978 / Q8N35722.420---
RPL226146 / P352681.831.350.163.832.840.01
NLE154475 / Q9NVX21.50.780.073.51.820
DAD11603 / P6180310.960.143.850
FBL2091 / P2208710.580.131.730
EIF63692 / P5653710.760.13.52.680
ACOT923597 / Q9Y3050.830.170.185.831.20.01
AKAP910142 / Q999960.831.020.1822.3327.450
MTCL123255 / Q9Y4B50.830.420.4214.837.440.01
CCDC138165055 / Q96M890.080.030.329.583.020.01
IPO955705 / Q96P70000.6231.0827.120
CEP13122994 / Q9UPN4---7.56.960
CEP7884131 / Q5JTW2---7.33229.610
SYNPO2171024 / Q9UMS6---3.3332.550.01
BEGAIN57596 / Q9BUH8---4.51170
SSX2IP117178 / Q9Y2D8---4.511.140
CDR21039 / Q01850---5.5839.640.01
YKT610652 / O15498---5.750.830.01
BRAP8315 / Q7Z569---17.51300
PKP311187 / Q9Y446---14.4221.30
CDR2L30850 / Q86X02---4Infinity0
TRAK266008 / O60296---3.5130
NUP18823511 / Q5SRE5---4.334.360.01
CHRAC154108 / Q9NRG0---3.5Infinity0
YTHDF154915 / Q9BYJ9---84.430.01
CEP7255722 / Q9P209---4.334.420.01
VPS3555737 / Q96QK1---7Infinity0
CEP1359662 / Q66GS9---4Infinity0
UTP1584135 / Q8TED0---20.790
AMOTL1154810 / Q8IY63---4.8394.420.01
SLC35B2347734 / Q8TB61---2.51.060
RPS3A6189 / P61247---8.8315.330.01
PKP48502 / Q99569---2.53.710
RBM4754502 / A0AV96---3.334.950.01
NAV289797 / Q8IVL1---14.254940
NAV389795 / Q8IVL0---9.67Infinity0
CDK5RAP255755 / Q96SN8---10.922.680.01
HM1381502 / Q8TCT9---5.51.150
LATS226524 / Q9NRM7---3.510.110
KIAA07539851 / Q2KHM9---4.5180
ANGEL123357 / Q9UNK9---20.620
SIPA1L257568 / Q9P2F8---37.80
CHUK1147 / O15111---2.510.830
GFM185476 / Q96RP9---20.760
NOL979707 / Q5SY16---2.51.670
CARD684674 / Q9BX69---2Infinity0
TOP3B8940 / O95985---4.57.090
ARHGAP3980728 / Q9C0H5---37.80