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Identifier
NSP14

Gene
ORF1ab
Protein name
Replicase polyprotein 1ab – Proofreading exoribonuclease
Localization
cytoplasm
Uniprot
P0DTD1
Description

Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. Acts as a proofreading exoribonuclease for RNA replication, thereby lowering The sensitivity of the virus to RNA mutagens. (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

AENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQ
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

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Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

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Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
RPS276232 / P426772.750.370.3112.751.730.01
FSCN16624 / Q166580.580.050.2321.081.830
RPL36122 / P39023000.6261.51.610
PAFAH1B15048 / P43034---14.171.560
RPL96133 / P32969---30.810
RPL76129 / P18124---8.251.250.01
RPL18A6142 / Q02543---10.51.780
RPL216144 / P46778---40.790
RPL306156 / P62888---41.190
RPL27A6157 / P46776---4.671.140.01
RPS66194 / P62753---4.331.020.01
LCLAT1253558 / Q6UWP7---71.890
RPS96203 / P46781---6.831.790
BUB39184 / O43684---30.830
RPS246229 / P62847---31.060
MYADM91663 / Q96S97---62.690
AP2M11173 / Q96CW1---91.030
ACOT923597 / Q9Y305---3.330.670.01
PRMT510419 / O14744---4.51.270
PSMB55693 / P28074---30.550
DERL179139 / Q9BUN8---6.672.30.01
RPN26185 / P04844---20.421.740
RCC255920 / Q9P258---11.51.270
TMX251075 / Q9Y320---6.51.370
NAT1055226 / Q9H0A0---11.421.140.01
TMEM205374882 / Q6UW68---51.820
PTGR122949 / Q14914---5.830.780.01
DHCR71717 / Q9UBM7---101.660
PLRG15356 / O43660---3.51.720
ABCG29429 / Q9UNQ0---4.51.020
TP53I119537 / O14683---3.52.120
DYNC1I21781 / Q13409---2.50.670
DARS11615 / P14868---10.331.50
EIF2S31968 / P41091---11.581.310.01
ARF4378 / P18085---6.51.180
SOAT16646 / P35610---30.590
GPAA18733 / O43292---3.54.440
EIF2S11965 / P05198---8.51.520
CAD790 / P27708---6.330.630.01
DDX39B7919 / Q13838---60.840
COPB29276 / P35606---5.830.650.01
DDOST1650 / P39656---2.51.130
ARPC1B10095 / O15143---7.831.430
CDIPT10423 / O14735---2.52.830
SEC23A10484 / Q15436---4.51.160
MCM54174 / P33992---17.51.420
SNRPD16632 / P62314---5.51.570
FADS13992 / O60427---41.010
TRAM123471 / Q15629---122.250
GHITM27069 / Q9H3K2---63.430
TM9SF49777 / Q92544---51.480
HSD17B1151170 / Q8NBQ5---51.580
HACD351495 / Q9P035---15.751.580
SLC35F654978 / Q8N357---22.420
TMEM3355161 / P57088---92.050
SMU155234 / Q2TAY7---11.52.490
TM9SF356889 / Q9HD45---3.50.80
WDR1857418 / Q9BV38---5.51.850
MAGT184061 / Q9H0U3---51.710
TECR9524 / Q9NZ01---9.331.450
STT3A3703 / P46977---30.50
SLC35B2347734 / Q8TB61---31.280
STT3B201595 / Q8TCJ2---60.440
RPL136137 / P26373---4.671.050.01
RPL266154 / P61254---11.421.730
RPL36AL6166 / Q969Q0---41.520
RPS36188 / P23396---19.331.260
CES11066 / P23141---10.080.940
VDAC37419 / Q9Y277---31.370
NCEH157552 / Q6PIU2---4.51.190
SLC25A4291 / P12235---32.332.010
SLC27A211001 / O14975---31.160
RAB2A5862 / P61019---51.440
EIF63692 / P56537---2.51.860
PRMT13276 / Q99873---7.51.250
ATP2A2488 / P16615---11.170.320.01
DDX219188 / Q9NR30---30.51.640
CLTC1213 / Q00610---52.581.520
SRC6714 / P12931---4.750.710.01
ACOT711332 / O00154---101.870
SEC61A129927 / P61619---2.51.110
RAB8A4218 / P61006---122.590
RAB3511021 / Q15286---131.990
RAB1A5861 / P62820---12.831.280.01
RAB1451552 / P61106---61.20
RAB135872 / P51153---8.52.870
MBOAT779143 / Q96N66---13.831.450
HM1381502 / Q8TCT9---71.480
NOL1079954 / Q9BSC4---4.52.520
SCAMP310067 / O14828---20.560
SCD6319 / O00767---2.50.710
CERS229956 / Q96G23---41.530