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Identifier
NSP15

Gene
ORF1ab
Protein name
Replicase polyprotein 1ab – Uridylate-specific endoribonuclease
Localization
cytoplasm
Uniprot
P0DTD1
Description

Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

SLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQ
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

Zoom:

Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

Zoom:

Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
FLII2314 / Q1304564.4212.64077.9215.290
CACYBP27101 / Q9HB7120.178.17048.6719.70
TRAF3IP210758 / O4373414.5Infinity01Infinity0.1
ATRX546 / P461006.174.830---
SNRPD16632 / P623144.51.270---
PSMB45692 / P2807039.180---
HPGD3248 / P15428211.560---
DBT1629 / P11182---41.560
CAPN723473 / Q9Y6W3---4.558.50
SACS26278 / Q9NZJ4---4Infinity0
PNPT187178 / Q8TCS8---23.332.420.01
PPHLN151535 / Q8NEY8---2.57.650
CHD11105 / O14646---76.870
MBOAT779143 / Q96N66---3.330.340.01
COX5B1329 / P10606---21.550