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Identifier
NSP16

Gene
ORF1ab
Protein name
Replicase polyprotein 1ab – 2'-O-methyltransferase
Localization
mitochondrion
Uniprot
P0DTD1
Description

Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system. (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

SSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

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Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

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Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
DHX81659 / Q1456251176.8096332.80
INTS257508 / Q9H0H028.8340.92027.8339.50
KLC264837 / Q9H0B627.758.69016.755.250.21
NRIP18204 / P4855224.176.99018.675.40.1
APC324 / P2505422.425.80.5378.4220.280
MEIOC284071 / A2RUB119.755.420.1632.758.990
RALGAPA1253959 / Q6GYQ0194940143640
IBTK25998 / Q9P2D016.9213.660.0126.4221.330
LAP351056 / P2883813Infinity056Infinity0
ERC123085 / Q8IUD2123.80.3841130
CDK5RAP255755 / Q96SN811.423.01018.424.860
TTC47268 / O95801116.7306.53.980
YTHDF154915 / Q9BYJ99.55.430.01---
SPICE1152185 / Q8N0Z39.336.710.4126.3318.940
PHLDB290102 / Q86SQ09.174.70.3534.6717.790
UGGT156886 / Q9NYU290.3603.50.140
C2CD326005 / Q4AC948.083.540.1818.588.140
NCOA48031 / Q137727.922.610.2412.924.250.01
USP349736 / Q70CQ27.081.670.1912.582.970
ZNF29223036 / O602815.512.430---
OFD18481 / O756655.333.060.2515.338.80
UBR551366 / O950715.2522.750.012.259.750.16
FKBP42288 / Q02790511.820---
SNX751375 / Q9UNH64.836.560.3416.8322.870
CHD684181 / Q8TD264.753.190.01---
SUGT110910 / Q9Y2Z04.673.660.01---
USP2529761 / Q9UHP34.5Infinity018.5Infinity0
SIPA1L257568 / Q9P2F84.513.7603.510.710
ZGRF155345 / Q86YA34.55.440---
HPGD3248 / P154284.558.50---
CEP13122994 / Q9UPN444.8401416.930
AIP9049 / O0017049.45024.730
PPFIA18500 / Q13136412.240.199.529.060.01
COIL8161 / P384323.926.50.311.9219.770.01
AKAP910142 / Q999963.832.580.014.833.250.01
EIF4ENIF156478 / Q9NRA83.751.650.2511.755.180
NFKB14790 / P198383.5910133380
ARHGAP3980728 / Q9C0H53.5130622.290
IPO810526 / O153973.520.2205.531.780
PTGES310728 / Q151853.56.5023.710.05
OTUD454726 / Q018043.334.330.011.331.730.17
MICAL357553 / Q7RTP63.332.130.4722.8314.610.01
CCDC138165055 / Q96M892.580.870.2515.085.090
SREBF16720 / P369562.50.207.50.610
CEP7255722 / Q9P2092.332.70.027.338.480.01
MYO1C4641 / O0015924.520---
INTS725896 / Q9NVH21.5Infinity0.073Infinity0
PIBF110464 / Q8WXW31.59.750.074.529.250
SSX2IP117178 / Q9Y2D81.54.330.07617.330
RBM4754502 / A0AV961.332.10.174.336.830.01
PPP6R122870 / Q9UPN71.080.380.4521.087.470
DLD1738 / P09622---13.752.260.01
ALAS1211 / P13196---10.56.20
AHDC127245 / Q5TGY3---314.180
ACOT923597 / Q9Y305---8.831.860
GRSF12926 / Q12849---18.675.030
NDUFS24720 / O75306---4.53.60
PNPLA850640 / Q9NP80---3.832.640.01
GLS2744 / O94925---11.172.750.01
TRAP110131 / Q12931---60.928.390
DAPK31613 / O43293---3Infinity0
DBT1629 / P11182---8.53.560
RNH16050 / P13489---6520
SUCLA28803 / Q9P2R7---3.51.780
NDUFA104705 / O95299---12.423.990
TXNL19352 / O43396---71.080.01
GLUD12746 / P00367---21.730
TIMM4410469 / O43615---7.751.870.01
CLPX10845 / O76031---19.674.450
KIAA07539851 / Q2KHM9---3.512.130
ANGEL123357 / Q9UNK9---17.56.590
CDK5RAP151654 / Q96SZ6---76.620
CPSF253981 / Q9P2I0---3.8342.740.01
TRMT10C54931 / Q7L0Y3---74.040
NDUFV24729 / P19404---64.220
NDUFV34731 / P56181---4.332.140.01
FASTKD560493 / Q7L8L6---8.423.750.01
MRPS2464951 / Q96EL2---2.58.670
MRPL4584311 / Q9BRJ2---4.55.20
MCM884515 / Q9UJA3---39.180
CEP8984902 / Q96ST8---4.558.50
PNPT187178 / Q8TCS8---35.833.910
USP54159195 / Q70EL1---3.510.710
RUNDC1146923 / Q96C34---2.51.140
MRPS964965 / P82933---517.330
ETFA2108 / P13804---8.922.430.01
ATP5F1A498 / P25705---42.210
ACOT210965 / P49753---455.010
IFFO2126917 / Q5TF58---7.5Infinity0
CNKSR222866 / Q8WXI2---5Infinity0
NDUFS14719 / P28331---33.085.530
PFDN55204 / Q99471---4Infinity0
PRORP9692 / O15091---14.084.90
MRPS3560488 / P82673---4.55.20
NOL665083 / Q9H6R4---19.927.570
GTPBP1085865 / A4D1E9---55.910
SOGA1140710 / O94964---6.515.360.01
LRPPRC10128 / P42704---233.990
FASTKD222868 / Q9NYY8---2.53.420
CCDC1464770 / Q49A88---2.532.50
NADK2133686 / Q4G0N4---32.140
DAB2IP153090 / Q5VWQ8---3.5Infinity0
RNF109921 / Q8N5U6---2.55.650
COX5B1329 / P10606---43.30