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Identifier
NSP5

Gene
ORF1ab
Protein name
3C-like proteinase
Localization
cytoplasm
Uniprot
P0DTD1
Description

Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP). (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

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Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

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Preys

Condition legend
  • C145A: Cysteine to alanine mutation at residue 145
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C145A-NtC-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
S.C.
Spec.
FDR
CLTC1213 / Q0061019.080.570.175.582.25024.580.730
SLC25A35250 / Q0032517.750.980.4235.251.950.0114.750.810.45
ARHGEF1823370 / Q6ZSZ515.6778.650------
ISCU23479 / Q9H1K114.17120------
HACD351495 / Q9P03511.751.210.0121.752.23012.251.260.01
RPN26185 / P0484411.420.98021.421.8307.920.680.02
RNF21357674 / Q63HN810.759.090.2519.2516.280.0112.7510.780.07
RPL156138 / P6131310.50.920.2924.52.14090.790.33
RPL66128 / Q0287810.420.610.5141.922.44018.921.10.45
RPS36188 / P233968.330.550.1921.831.43014.330.940
RAB1B81876 / Q9H0U47.50.920.01121.4709.51.170
FSCN16624 / Q166587.080.620.0126.082.308.580.760.01
MYBL24605 / P102446.8316.940------
CCAR155749 / Q8IX126.83106.980------
RAB1A5861 / P628206.330.630.2513.331.340.017.330.730.24
RPS116205 / P622805.830.850.1911.831.7306.330.920.17
SLC2A16513 / P111665.830.920.1710.331.6205.330.840.19
AKR1B1231 / P151215.750.970.2311.251.890.014.750.80.25
PAFAH1B15048 / P430345.670.620.1713.171.4405.670.620.16
FADS29415 / O958645.670.740.1613.171.7104.670.610.19
ATP2A2488 / P166155.670.170.0138.671.16017.170.510
ARL6IP510550 / O759155.581.10.028.081.590.017.581.490.01
RPL7A6130 / P624245.50.670.03151.82050.610.16
MCM54174 / P339925.50.46027.52.31090.760
TECR9524 / Q9NZ015.330.850.0113.332.1205.330.850.01
RAB3511021 / Q1528650.770.16142.1506.510.02
MAP4K49448 / O9581956.840------
CASKIN257513 / Q8WXE051300------
MBOAT779143 / Q96N664.830.510.0113.831.4504.330.460.01
USP9X8239 / Q930084.8312.370.01------
WDR19948 / O750834.750.580.1712.251.4902.250.270.25
TRAM123471 / Q156294.50.840112.05030.560.04
RAB8A4218 / P610064.50.9509.52.0102.50.530.05
RPL13A23521 / P404294.330.70.2117.332.7903.330.540.24
MGST14257 / P1062040.850.1971.490.0140.850.16
DDX219188 / Q9NR3040.220.3351.890170.920
RPS27L51065 / Q71UM540.830.0412.52.59040.830.04
KATNIP23247 / O60303420.80------
COPB29276 / P356063.830.450.0113.831.6104.830.560.01
RPS276232 / P426773.750.510.1911.751.590.015.750.780.25
STOM2040 / P271053.670.450.039.171.1203.670.450.03
RPL18A6142 / Q025433.50.5908.51.4303.50.590
EIF2S11965 / P051983.50.6309.51.7204.50.810
ACOT711332 / O001543.50.6509.51.77071.30
SNRPD16632 / P623143.51.020.0472.030---
RPL36AL6166 / Q969Q03.51.407.530---
TRMT155621 / Q9NXH93.545.50------
RPL266154 / P612543.420.510.219.921.490.013.420.510.22
ARPC1B10095 / O151433.330.620.0110.331.9304.830.90.01
RPL76129 / P181243.250.520.0316.252.5906.2510.01
CES11066 / P231413.080.290.1614.081.3303.080.290.19
STT3A3703 / P4697730.530111.95050.880
STT3B201595 / Q8TCJ230.230181.36020.150.05
HM1381502 / Q8TCT930.64081.7071.490
ZNF5929640 / Q926103130------
RPL276155 / P613532.920.580.218.421.680.013.920.780.21
RPL27A6157 / P467762.670.670.198.172.0604.671.180.01
TMX251075 / Q9Y3202.50.52040.83040.830
RPL136137 / P263732.170.510.210.172.402.670.630.19
CPNE18904 / Q998292.170.970.24.171.860.011.670.740.21
EIF4A11973 / P608422.080.370.2710.581.870.011.580.280.29
PIGU128869 / Q9H49020.57041.1401.50.430.07
AP2M11173 / Q96CW11.50.180.0713.51.58050.590
DDX39B7919 / Q138381.50.210.0791.29050.710
RPL216144 / P467781.50.310.0711.52.4103.50.730
DHCR71717 / Q9UBM71.50.240.0771.14020.320.05
CLPTM11209 / O960051.50.170.0791.04020.230.05
RPS66194 / P627531.330.330.178.332.040---
ALDOA226 / P040751.250.290.177.251.660.013.750.860.02
PSMD35709 / O432421.250.270.279.2520.014.250.920.23
COTL123406 / Q140191.080.20.318.081.490.013.580.660.25
RPL239349 / P6282910.340.151.68010.340.1
RPS246229 / P6284710.360.13.51.2502.50.890
PRMT13276 / Q9987310.170.111.51.97030.510
SLC7A1123657 / Q9UPY510.250.16.51.59040.980
TM9SF356889 / Q9HD4510.230.15.51.2803.50.820
MAGT184061 / Q9H0U310.350.17.52.65031.060
SLC27A211001 / O1497510.390.12.50.960---
PTGR122949 / Q149140.830.110.189.831.3403.330.450.02
SUPT16H11198 / Q9Y5B90.420.10.289.422.2302.920.690.23
RPL286158 / P467790.330.050.3918.332.920.016.831.090.21
TCP16950 / P179870.170.030.3411.171.8802.170.370.25
NPC14864 / O15118---3.50.7402.50.530
RPL96133 / P32969---41.0901.50.410.07
RPL186141 / Q07020---5.171.640.012.670.850.17
RPS76201 / P62081---4.171.110.012.170.580.16
RPS96203 / P46781---10.332.8101.830.50.16
MYADM91663 / Q96S97---3.51.501.50.640.07
ACOT923597 / Q9Y305---2.330.470.023.830.770.01
CDC42998 / P60953---20.490.0561.470
PSMB55693 / P28074---8.51.6203.50.670
RCC255920 / Q9P258---16.51.8602.50.280
TMEM205374882 / Q6UW68---51.8202.50.910
NSUN254888 / Q08J23------3.520.220
DARS11615 / P14868---13.331.9703.330.490.01
RPN16184 / P04843---81.03010.130.1
CAD790 / P27708---9.830.9903.330.330.01
MPDU19526 / O75352---3201.510.07
ABCC14363 / P33527---110.5404.50.220
PAPSS19061 / O43252------3.33Infinity0.01
ZMPSTE2410269 / O75844---5.51.5901.50.430.07
TBL310607 / Q12788---51.87010.370.1
YKT610652 / O15498---5.250.760.013.250.470.02
NUP18823511 / Q5SRE5---2.832.910.024.834.960.01
TMEM3355161 / P57088---4.50.99020.440
SMU155234 / Q2TAY7---61.2401.50.310.07
TMTC3160418 / Q6ZXV5---10.090.140.340
ABCC21244 / Q92887---70.77020.220.05
ATP2B1490 / P20020---5.50.69030.380
NCEH157552 / Q6PIU2---82.2020.550.05
PPP1CC5501 / P36873------53.880
MCU90550 / Q8NE86---4.55.09011.130.1
ACSL32181 / O95573---6.50.47010.070.1
SLC1A56510 / Q15758---61.25051.040
RPL106134 / P27635------2130
SEC23A10484 / Q15436---51.29030.780
RAB1451552 / P61106---10.52.1804.50.930
RAB135872 / P51153---6.52.14030.990.04
RAB3B5865 / P20337---42.77021.390
ZBTB12221527 / Q9Y330---1Infinity0.13.5Infinity0
TMED210959 / Q15363---21.68010.840.1
SDHA6389 / P31040------2.50.860
PIAS451588 / Q8N2W9------2.510.830
RAB2A5862 / P61019---5.51.59020.580
RAB8B51762 / Q92930---81.99020.50.05
RPL35A6165 / P18077---61.91020.640.05
SLC16A16566 / P53985---6.52.68010.410.1
VPS26A9559 / O75436---2.51.94010.780.1
ARF4378 / P18085---4.50.8020.360.05
ARL8B55207 / Q9NVJ2---4.52.15010.480.1
CYBA1535 / P13498---2.52.360---
DDB21643 / Q92466---3.52.360---
RB15925 / P06400---47.430---
RPL86132 / P62917---4.51.630---
RPL126136 / P30050---3.52.190---
RPL306156 / P62888---4.51.340---
SEH1L81929 / Q96EE3---3.55.350---
PRMT510419 / O14744---61.720---
TFRC7037 / P02786---4.50.750---
SLC39A1423516 / Q15043---3.51.560---
TMEM106B54664 / Q9NUM4---41.690---
ARL1400 / P40616---31.510---
POGZ23126 / Q7Z3K3---4.56.880---
PLRG15356 / O43660---7.53.980---
EIF3L51386 / Q9Y262---43.150---
WDR410785 / P57081---36.240---
DYNC1I21781 / Q13409---4.51.230---
ADAM98754 / Q13443---40.620---
COX151355 / Q7KZN9---21.580---
TM9SF29375 / Q99805---31.040---
SLC27A410999 / Q6P1M0---41.180---
DDOST1650 / P39656---31.370---
NNT23530 / Q13423---50.960---
FADS13992 / O60427---3.50.880---
SACM1L22908 / Q9NTJ5---62.480---
FLVCR128982 / Q9Y5Y0---31.180---
DHCR241718 / Q15392---62.710---
WDR4323160 / Q15061---2.52.360---
TMEM16054958 / Q9NX00---2.54.060---
SLC35F654978 / Q8N357---33.80---
AGPAT555326 / Q9NUQ2---21.350---
CERS229956 / Q96G23---4.51.730---
ERMP179956 / Q7Z2K6---2.51.090---
TMEM24523731 / Q9H330---32.080---
WDR7584128 / Q8IWA0---7.54.290---
UTP1584135 / Q8TED0---2.50.990---
LRWD1222229 / Q9UFC0---2.52.280---
SLC35B2347734 / Q8TB61---73.190---
CARM110498 / Q86X55---22.810---
ATP1A1476 / P05023---8.51.470---
VDAC37419 / Q9Y277---4.52.110---
RGPD3653489 / A6NKT7---449.420---
SRC6714 / P12931---5.250.790.01---
LCLAT1253558 / Q6UWP7---4.51.180---
PPAN-P2RY11692312 / ----23.150---
TTC2755622 / Q6P3X3---32.40---
BUB39184 / O43684---3.50.970---
SLC16A39123 / O15427---21.210---
RFT191869 / Q96AA3---21.280---
HNRNPLL92906 / Q8WVV9---33.180---
LTA4H4048 / P09960---21.550---
GGCT79017 / O75223---22.170---
AP3M126985 / Q9Y2T2---2.53.820---
TMCO154499 / Q9UM00---21.760---
RPL326161 / P62910---34.330---
RPS4Y16192 / P22090---4.52.60---
AGTRAP57085 / Q6RW13---23.350---