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Identifier
NSP8

Gene
ORF1ab
Protein name
Replicase polyprotein 1ab – Non-structural protein 8
Localization
cytoplasm
Uniprot
P0DTD1
Description

Plays a role in viral RNA synthesis. Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

AIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQ
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

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Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

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Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
MGA23269 / Q8IWI997.424.32050.422.240.56
BRCA2675 / P5158785.923.17052.421.940.44
POLR3A11128 / O148028126.83029.59.770
DDB11642 / Q1653152.516.7503310.530
HECTD125831 / Q9ULT845390067580.670
SMC1A8243 / Q1468335.515.78027.512.220
MTR4548 / Q9970735.256.11031.255.420.02
SMC410051 / Q9NTJ330.1718.58030.6718.890
HERC18925 / Q1575125650036.59490
PRPF810594 / Q6P2Q9252.430.42403.880.01
PRKDC5591 / P7852724.56.5022.55.970
CAD790 / P2770823.332.47021.332.250
EFTUD29343 / Q1502922.337.17015.334.920.22
FLII2314 / Q1304521.422.970.0122.923.180.01
POLR2B5431 / P3087618.429.70.0116.928.910.02
MCM44173 / P3399117.9215.96043.4238.660
GBE12632 / Q0444617.757.380.1720.258.420.01
MCM74176 / P3399317.175.58017.175.580
RBBP75931 / Q1657615.8380.0111.835.980.17
APPL255198 / Q8NEU813.423.60.0119.425.220
UBA17317 / P2231412.3315.29011.8314.670
GNAS2778 / O9546712.3311.07011.3310.170
CPNE18904 / Q9982912.176.28010.675.510
PSMC15700 / P62191122.450122.450
TTC379652 / Q6PGP7127.520.0185.010.01
PFAS5198 / O1506711.584.58010.083.990.01
CLUH23277 / O7515311.584.940.018.583.660.16
MAGED19500 / Q9Y5V311.54.670.16156.090.01
ALDH3A2224 / P5164811.170.810.0112.170.880.01
VPS13A23230 / Q96RL7105.6505.53.110
SPG1180208 / Q96JI79.8346.5504.3320.510.01
DDRGK165992 / Q96HY69.671.53013.172.090
NHLRC2374354 / Q8NBF29.339.2809.339.280
PSMD25708 / Q132009.251.670.0111.252.030.01
PSMC45704 / P436868.59.820.0711.513.290.01
ZNF50722847 / Q8TCN58.4211.610.018.4211.610.01
WDR3557539 / Q9P2L07.6719.270.0111.1728.060
RRM16240 / P239217.3340.90.014.8326.950.01
UBA655236 / A0AVT1724.2706.522.530
DPP991039 / Q86TI271.98030.850
MED13L23389 / Q71F566.926.480.015.925.540.1
CDK5RAP255755 / Q96SN86.921.70.111.422.810
PHB5245 / P352326.8321.3401.334.160.17
SND127044 / Q7KZF46.52.190.016.52.190.01
WDR72256764 / Q3MJ136.50.71040.440
CDC168881 / Q130426.088.920.015.588.190.01
NUP1559631 / O756946.080.650.014.080.430.16
EIF2AK4440275 / Q9P2K86Infinity01.5Infinity0.07
MAN2C14123 / Q9NTJ4662.40772.80
NPEPPS9520 / P557865.57.7301723.890
VPS13B157680 / Q7Z7G85.50.38060.420
ME14199 / P481635.336.770.015.336.770.01
MED139969 / Q9UHV7543.330---
MCM884515 / Q9UJA34.516.710311.140
E2F879733 / A0AVK64.175.20.013.173.950.16
PRMT990826 / Q6P2P24Infinity01.5Infinity0.07
UCHL17345 / P09936413039.750
ALDOA226 / P040753.750.840.024.250.950.01
AKAP1011216 / O435723.672.010.3217.179.420
INTS1481556 / Q96SY03.591041040
ZGRF155345 / Q86YA33.54.04022.310.05
ATR545 / Q135353.520.220---
DRG14733 / Q9Y2953.339.120.012.837.750.02
USP118237 / P517843.334.910.012.333.430.02
CC2D2A57545 / Q9P2K137803780.04
DLST1743 / P3695739.7504130
DMWD1762 / Q0901937801260.1
SLC4A26522 / P0492030.270---
ESPL19700 / Q14674311.140---
CAPN2824 / P17655322.290---
USP349736 / Q70CQ22.580.650.2919.584.940
HERC426091 / Q5GLZ82.514.440211.560
RIC8B55188 / Q9NVN32.56501260.1
PJA29867 / O431642.543.3303520.04
SDHA6389 / P310402.50.860---
MYO1C4641 / O0015924.7302.55.910
MTA357504 / Q9BTC8220.80110.40.1
SKIV2L6499 / Q154771.8316.810.164.3339.780.01
ECD11319 / O959051.753.960.179.7522.040
DDX60L91351 / Q5H9U91.671.590.339.679.190.01
SKAP28935 / O755631.560.073.5140
UBR3130507 / Q6ZT121.57.80.073.518.20
RPL296159 / P4791411.630.123.250
CORO1B57175 / Q9BR7611.270.12.53.170
CBWD5220869 / Q5RIA916.50.14260
VAC1455697 / Q08AM611.930.14.58.670
PRMT13276 / Q9987310.160.12.50.40
ASMTL8623 / O956710.830.890.185.335.740.01
COPB11315 / P53618000.6244.510.380.01
RPL18A6142 / Q02543---3.50.570
TRIM374591 / O94972---4.835.550.01
RO606738 / P10155---3Infinity0
TMEM205374882 / Q6UW68---20.70
ECHS11892 / P30084---2.54.480
PTGES310728 / Q15185---47.70
RBBP45928 / Q09028---96.690
DDX2011218 / Q9UHI6---3.338.830.01
APAF1317 / O14727---39.750
PANK455229 / Q9NVE7---2520
DYRK1A1859 / Q13627---2.5Infinity0
DBT1629 / P11182---20.760