Identifier
ORF3A

Gene
ORF3a
Protein name
ORF3a protein
Localization
ER, Golgi
Uniprot
Description

Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination. (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

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Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

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Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
GOLGA42803 / Q13439142.922.310---
LRBA987 / P50851132.589.850---
NEDD1121441 / Q8NHV4115.1783.090---
RPS27A6233 / P6297997.335.98014.830.910.04
CLTC1213 / Q0061088.082.66019.580.590.04
TRIP119321 / Q15643831.44060.10.19
CEMIP223670 / Q9UHN678.253.1709.250.370.2
CLCC123155 / Q96S6668.58.3033.54.060
ROR14919 / Q019736343.680---
NEO14756 / Q9285957.585.070---
RPL36122 / P3902355.51.450130.340.56
VPS3923339 / Q96JC149Infinity022.5Infinity0
SLC4A79497 / Q9Y6M748.253.4401.250.090.5
ITGB53693 / P18084482.79050.290.04
ATP2A2488 / P1661546.671.43057.671.770
DDX219188 / Q9NR3046.52.5809.50.530.1
IGF2R3482 / P1171745.831.6303.830.140.25
COPA1314 / P5362144.252.4706.250.350.45
NUMB8650 / P4975743.511.370---
SREBF26721 / Q12772413.460181.520
GOLGA22801 / Q0837939.172.90000.62
SLC25A4291 / P1223537.332.340---
RPS36188 / P2339636.832.51013.330.910.03
ANKLE223141 / Q86XL336.580.930.0131.080.790.04
SLC4A26522 / P04920333.290111.10
COPB29276 / P3560632.334.105.330.680.07
MCM54174 / P33992312.63070.590.03
PFKP5214 / Q0181330.922.7501.920.170.43
PDXDC123042 / Q6P99629.920.910000.51
NBEA26960 / Q8NFP929.9211.690---
NUMBL9253 / Q9Y6R029.6712.080---
RECQL5965 / P4606326.53.180.01000.62
SLC12A26558 / P5501126.331.68024.831.590
AMIGO2347902 / Q86SJ225.54.77030.560
SREBF16720 / P3695625.52.209.50.820
PAFAH1B15048 / P4303424.672.8405.170.60.16
RCC255920 / Q9P258242.8040.470
MRC29902 / Q9UBG024120---
FAT12195 / Q1451723.51.1903.50.180.04
TBL310607 / Q1278823.511.980---
CYP51A11595 / Q16850231.410462.820
ACSL32181 / O9557322.51.7011.50.870
ABCC14363 / P3352722.51.16031.51.620
NAT1055226 / Q9H0A022.422.3301.920.20.31
TFRC7037 / P0278621.54.0502.50.470.05
RAB1010890 / P6102621.331.910.016.330.570.44
LRP64040 / O75581213.4010.160.1
PCDH95101 / Q9HC56216.070---
SUPT16H11198 / Q9Y5B920.425.3600.920.240.26
WDR19948 / O7508320.252.5603.250.410.16
ATP2B1490 / P20020202.7109.51.290
DARS11615 / P1486819.833.0403.330.510.1
NNT23530 / Q1342319.54.1701.50.320.07
PTPRJ5795 / Q1291319.55.280---
NDC155706 / Q9BTX119.421.33011.920.820
SEC22B9554 / O7539619.171.250.0115.671.020.17
CPD1362 / O7597618.52.960---
RPN26185 / P0484418.421.5605.920.50.16
NETO281831 / Q8NC67182.39010.130.1
INAVA55765 / Q3KP6617.8311.230---
EIF3B8662 / P5588417.753.150000.36
EIF2S31968 / P4109117.582.0401.080.130.3
CES11066 / P2314117.581.6805.580.530.05
ADAM98754 / Q1344317.52.9504.50.760.04
SRC6714 / P1293117.252.770---
GULP151454 / Q9UBP917.2515.60---
FSCN16624 / Q1665817.081.4605.580.480.02
STT3B201595 / Q8TCJ2171.2806.50.490
LGR455366 / Q9BXB116.831.5106.330.570.01
ATF622926 / P1885016.53.801.50.350.07
SMU155234 / Q2TAY716.53.73030.680.04
LRIG3121227 / Q6UXM116.53.550---
HACD351495 / Q9P03516.251.6306.250.630.25
RPN16184 / P04843162.16060.810
RAB1A5861 / P6282015.831.608.830.890.21
TCP16950 / P1798715.672.7201.170.20.29
ABCC21244 / Q9288715.51.76010.51.190
AUP1550 / Q9Y67915.50.720251.160
PRMT13276 / Q9987315.52.73020.350.05
EPN222905 / O9520815.56.150---
DHCR71717 / Q9UBM7152.5701.50.260.07
MYRF745 / Q9Y2G1155.030---
SNX38724 / O6049314.924.290---
STX56811 / Q1319014.581.3506.580.610.21
RAB3511021 / Q1528614.52.2405.50.850.15
RPL7A6130 / P6242414.51.7602.50.30.17
EIF2S11965 / P0519814.52.7102.50.470.05
RAB1B81876 / Q9H0U414.51.8040.50.15
MBOAT779143 / Q96N6614.331.5105.330.560.01
RPS116205 / P6228014.332.1202.830.420.23
ARPC1B10095 / O1514314.332.7503.330.640.02
CAD790 / P2770814.331.4601.330.140.17
SNX179784 / Q1503614.258.230---
AP2M11173 / Q96CW1141.6401.50.180.07
DDX39B7919 / Q13838142.0601.50.220.07
VPS1664601 / Q9H26914242.670---
GOPC57120 / Q9HD2613.831.080---
AKR1B1231 / P1512113.752.3500.750.130.31
RPL76129 / P1812413.752.160---
ARF1375 / P8407713.671.9702.170.310.3
OSMR9180 / Q9965013.51.13018.51.550
SLC7A1123657 / Q9UPY513.53.550---
STOM2040 / P2710513.171.6403.170.390.16
VRK27444 / Q86Y0713.080.72017.080.940
RAB1451552 / P61106132.7502.50.530.05
EPHA21969 / P293171320---
WWOX51741 / Q9NZC7131.860---
RPL266154 / P6125412.921.9703.920.60.19
SLC2A16513 / P1116612.832.0503.330.530.23
PTGR122949 / Q1491412.831.770---
ABCC410257 / O1543912.51.56011.51.430
RPS27L51065 / Q71UM512.52.5905.51.140
SLC12A46560 / Q9UP9512.51.980---
AXL558 / P3053012.58.330---
TECR9524 / Q9NZ0112.331.9500.830.130.18
EIF4A11973 / P6084212.082.1603.080.550.22
CLPTM11209 / O96005121.41013.51.590
ARF4378 / P18085122.26030.570.04
SCAMP19522 / O15126123.570---
GPRC5A9052 / Q8NFJ511.922.350000.37
RPL13A23521 / P4042911.831.8403.330.520.24
POR5447 / P1643511.750.88011.750.880
HM1381502 / Q8TCT911.52.5203.50.770
BUB39184 / O4368411.53.48010.30.1
ACOT711332 / O0015411.52.1701.50.280.07
ARF5381 / P8408511.53.10---
FLVCR128982 / Q9Y5Y011.55.20---
PSMD35709 / O4324211.252.480.010.750.170.3
RPS276232 / P4267711.251.520.01---
USP3284669 / Q8NFA011.251.610---
MGST14257 / P10620112.4102.50.550.21
TMEM3355161 / P57088112.5502.50.580.05
RAB8A4218 / P61006112.350---
YKT610652 / O1549810.751.5903.250.480.03
RPL136137 / P2637310.672.5303.170.750.16
ANO6196527 / Q4KMQ210.670.470.0123.671.050
CISD2493856 / Q8N5K110.581.020.0113.581.310.01
SLC1A56510 / Q1575810.52.28061.30
RPL18A6142 / Q0254310.51.7801.50.250.07
PSMB55693 / P2807410.52.03010.190.1
STT3A3703 / P4697710.51.85030.530.04
ATP2B4493 / P2363410.53.48051.660.04
RPL35A6165 / P1807710.53.550---
ATP7A538 / Q0465610.331.640---
HGS9146 / O1496410.172.770.01---
RPL216144 / P46778102.07020.410
WDR1857418 / Q9BV38103.56010.360.1
RAB2A5862 / P61019103.0401.50.460.07
PRMT510419 / O14744103.01010.30.1
PWP25822 / Q15269108.130---
KIAA0319L79932 / Q8IZA0102.370---
MET4233 / P08581103.490---
RPS246229 / P628479.53.6901.50.580.07
RPL239349 / P628299.53.3801.50.530.07
GORASP226003 / Q9H8Y89.51.280---
RAB8B51762 / Q929309.52.40---
ALDOA226 / P040759.252.1501.250.290.17
FADS29415 / O958649.171.180.0111.671.510
RPL306156 / P6288892.8401.50.470.07
TRAM123471 / Q1562991.65010.180.1
TM9SF356889 / Q9HD4592.1701.50.360.07
FAM135A57579 / Q9P2D695.570---
SLC12A710723 / Q9Y66692.850---
ZDHHC525921 / Q9C0B58.754.970.01---
NPC14864 / O151188.51.8603.50.770
VAPA9218 / Q9P0L08.51.11081.040
CDC42998 / P609538.52.14010.250.1
HSD17B1151170 / Q8NBQ58.52.801.50.490.07
TOR4A54863 / Q9NXH88.52.6502.50.780.05
RAB135872 / P511538.52.8702.50.840.05
WDR310885 / Q9UNX48.512.280---
SACM1L22908 / Q9NTJ58.53.650---
PSMC15700 / P621918.51.690---
RPL276155 / P613538.421.680.012.420.480.23
SLC39A1423516 / Q1504383.8501.50.720.07
ATP1A1476 / P0502381.3802.50.430.05
SLC12A69990 / Q9UHW983.92010.490.1
APPL126060 / Q9UKG189.040---
UTP1584135 / Q8TED083.470---
ZDHHC1354503 / Q8IUH482.670---
TMEM21454867 / Q6NUQ47.50.8405.50.620
ABCG29429 / Q9UNQ07.51.75030.70
VDAC27417 / P458807.52.950.0131.180.19
TBL226608 / Q9Y4P37.52.06010.280.1
TM9SF49777 / Q925447.52.2801.50.460.07
CPT1A1374 / P504167.53.330---
DYNC1I21781 / Q134097.52.110---
SCAMP310067 / O148287.52.230---
PRPF1927339 / Q9UMS47.54.060---
DIP2B57609 / Q9P2657.512.190---
RPS96203 / P467817.331.9400.830.220.18
RPL186141 / Q070207.172.330.013.171.030.16
ARL6IP510550 / O759157.081.380.012.580.50.19
TMX251075 / Q9Y32071.49061.270
LCLAT1253558 / Q6UWP771.89010.270.1
VDAC37419 / Q9Y27773.43020.980.05
SLC35B2347734 / Q8TB6173.19010.460.1
SLC16A16566 / P5398572.910---
DDB11642 / Q1653171.430---
LNPEP4012 / Q9UIQ671.910---
DHCR241718 / Q1539273.220---
SEMA4C54910 / Q9C0C472.210---
RPL36AL6166 / Q969Q072.780---
PKP48502 / Q995697140---
TUBGCP210844 / Q9BSJ27Infinity0---
RAC15879 / P6300072.350---
RPS66194 / P627536.831.6503.330.80.01
DERL179139 / Q9BUN86.672.30.010.670.230.21
CDKAL154901 / Q5VV426.580.570.0113.081.140
DHRS39249 / O759116.50.92081.130
TMEM20984928 / Q96SK26.51.1504.50.790
STIM257620 / Q9P2466.50.55050.420.04
DDOST1650 / P396566.53.1601.50.730.07
ZMPSTE2410269 / O758446.51.9010.290.1
RNF149284996 / Q8NC426.52.3010.350.1
LRP54041 / O751976.51.39010.210.1
DPY19L123333 / Q2PZI16.52010.310.1
RPL86132 / P629176.52.410---
KIRREL155243 / Q96J846.54.450---
WDR7584128 / Q8IWA06.53.630---
PLD15337 / Q133936.524.140---
SEC61A129927 / P616196.53.10---
NLE154475 / Q9NVX26.53.60---
TMEM13123505 / Q925456.330.7206.830.780.01
RPL27A6157 / P467766.171.5300.670.170.22
EPB41L4B54566 / Q9H3296.1712.480.01---
SCD6319 / O0076761.7806.51.930
DNAJC1623341 / Q9Y2G860.6709.51.060
HMGCR3156 / P0403565.57032.790.04
NCEH157552 / Q6PIU261.6201.50.40.07
ABCB610058 / Q9NP586601.51.50.07
JAG1182 / P7850461.470---
ECE11889 / P4289261.020---
RAB7A7879 / P51149620---
SEC23A10484 / Q1543661.570---
MAGT184061 / Q9H0U362.080---
ABCC38714 / O154385.830.820.019.331.320.04
EFR3A23167 / Q141565.6711.770.01---
VAPB9217 / O952925.580.610.017.080.780.02
BOP123246 / Q141375.581.80.01---
GPAT384803 / Q53EU65.50.87050.80
FADS13992 / O604275.51.41041.020
RPL96133 / P329695.51.5301.50.420.07
SPINT210653 / O432915.51.0301.50.280.07
SOAT16646 / P356105.51.1020.40.05
SGPL18879 / O954705.51.54010.280.1
STEAP355240 / Q658P35.53.710---
EIF3L51386 / Q9Y2625.54.540---
FURIN5045 / P099585.51.710---
NARS14677 / O437765.55.40---
ATP9A10079 / O751105.512.430---
SNRPD16632 / P623145.51.570---
DPP991039 / Q86TI25.51.530---
RPS4X6191 / P627015.53.810---
MGRN123295 / O602915.523.830---
APBB2323 / Q928705.53.250---
LRP87804 / Q141145.55.840---
ZFYVE99372 / O954055.547.670---
ARPC1A10552 / Q927475.53.620---
STBD18987 / O952105.330.490.0110.330.960
ACOT923597 / Q9Y3055.331.090.01---
TOMM4010452 / O960085.333.140.01---
BMP2K55589 / Q9NSY15.335.990.01---
MYADM91663 / Q96S9752.2031.320
FNDC3A22862 / Q9Y2H650.54040.440.04
TMEM205374882 / Q6UW6851.82020.730.05
SLC25A101468 / Q9UBX353.51010.70.1
SLC27A410999 / Q6P1M051.49030.90.04
SCARB1949 / Q8WTV050.902.50.450.05
SERPINH1871 / P5045451.08020.430.05
ARL8B55207 / Q9NVJ252.41010.480.1
CLCN71186 / P5179852.890---
PLRG15356 / O4366052.520---
OCLN100506658 / Q1662553.250---
CA12771 / O4357052.680---
SHB6461 / Q154645130---
NEMF9147 / O6052452.950---
DCBLD2131566 / Q96PD251.740---
ERBB22064 / P0462652.340---
OSBPL8114882 / Q9BZF14.750.740.013.250.50.16
RPS76201 / P620814.671.250.01---
JAK13716 / P234584.672.280.01---
TYW155253 / Q9NV664.50.4805.50.590
ADGRG657211 / Q86SQ44.50.7602.50.420.05
OSBP5007 / P220594.52.8201.50.940.07
RUSF164755 / Q96GQ54.51.6301.50.540.07
RCC11104 / P187544.52.410---
UNC93B181622 / Q9H1C44.53.60---
RFT191869 / Q96AA34.53.080---
CD44960 / P160704.55.20---
CXADR1525 / P783104.53.60---
FERMT155612 / Q9BQL64.57.550---
PTPN15770 / P180314.250.420.029.250.920.01
PIGU128869 / Q9H49041.14041.140
SMPD455627 / Q9NXE440.65050.810
RAB11A8766 / P6249142.63021.320.05
C1orf4325912 / Q9BWL341.44041.440.04
ATRN8455 / O7588241.7802.51.110.05
RER111079 / O1525841.91010.480.1
RHBDF279651 / Q6PJF542.080---
XPR19213 / Q9UBH642.670---
UBAC2337867 / Q8NBM443.850---
RAB5C5878 / P5114843.30---
CUEDC1404093 / Q9NWM346.30---
MPDU19526 / O7535242.740---
CTDSP210106 / O1459544.950---
SLC5A68884 / Q9Y289480---
GFM185476 / Q96RP941.580---
LRWD1222229 / Q9UFC043.850---
GOSR19527 / O9524940.690---
DYNLL18655 / P6316743.530---
MFGE84240 / Q0843144.330---
FBL2091 / P2208742.360---
RPL226146 / P352683.832.840.010.830.610.18
LRP44038 / O750963.834.860.01---
EPHX12052 / P070993.50.53081.220
TEX26451368 / Q9Y6I93.50.36013.51.380
UBXN423190 / Q925753.50.5406.51.010
TMTC3160418 / Q6ZXV53.50.30100.870
FKBP823770 / Q143183.50.79040.90
MICAL29645 / O948513.50.64020.370.05
RAB2123011 / Q9UL253.52.0701.50.890.07
PRR1155771 / Q96HE93.50.83020.480.05
TMX181542 / Q9H3N13.50.86020.490.05
GPAT4137964 / Q86UL33.50.9020.510.05
RPL126136 / P300503.52.190---
RPL37A6168 / P615133.53.370---
SLC35A27355 / P783813.51.940---
SLC38A181539 / Q9H2H93.52.250---
IMMT10989 / Q168913.52.360---
TMEM106B54664 / Q9NUM43.51.470---
SEC136396 / P557353.51.90---
TBC1D2457465 / Q9ULP93.5910---
WDR410785 / P570813.57.580---
PRKCI5584 / P417433.54.440---
COX151355 / Q7KZN93.52.890---
CERS229956 / Q96G233.51.330---
ERMP179956 / Q7Z2K63.51.560---
VKORC1L1154807 / Q8N0U83.52.170---
VPS26A9559 / O754363.52.80---
TP53I119537 / O146833.52.120---
BET1L51272 / Q9NYM93.51.560---
BET110282 / O1515530.6802.50.570
GRAMD1A57655 / Q96CP630.405.50.740
CYB5A1528 / P0016730.8106.51.760
PPIB5479 / P2328430.8020.530.05
DGKE8526 / P5242931.4601.50.730.07
TM9SF29375 / Q9980531.04010.350.1
ATP13A157130 / Q9HD2030.7607.51.90.03
AAAS8086 / Q9NRG930.7101.50.360.07
RPS166217 / P6224933.90---
SLC16A39123 / O1542731.860---
GLG12734 / Q9289630.350---
SORD6652 / Q0079631.50---
STXBP36814 / O0018635.780---
GHITM27069 / Q9H3K231.610---
GPRC5C55890 / Q9NQ8432.690---
SLC38A254407 / Q96QD832.260---
ACBD364746 / Q9H3P730.620---
TMEM24523731 / Q9H33032.080---
GPRIN1114787 / Q7Z2K83390---
EIF63692 / P5653732.260---
ABCB722 / O7502732.170---
TMEM201199953 / Q5SNT230.950---
PREB10113 / Q9HCU52.50.9020.720.05
ARHGDIA396 / P525652.52.17010.870.1
DDB21643 / Q924662.51.650---
PNP4860 / P004912.52.030---
RPS266231 / P628542.54.190---
PLD323646 / Q8IV082.51.140---
SUN123353 / O949012.50.290---
ARL1400 / P406162.51.250---
BMPR2659 / Q138732.54.810---
NOL1079954 / Q9BSC42.51.340---
SEC24C9632 / P539922.50.630---
CPSF129894 / Q105702.56.840---
AGPAT555326 / Q9NUQ22.51.710---
UTP484916 / Q969X62.53.510---
RAB3483871 / P0DI832.51.630---
FZD22535 / Q143322.52.20---
GNPDA110007 / P469262.57.650---
TLCD4148534 / Q96MV12.57.220---
S1PR31903 / Q995002.52.890---
GPR89A653519 / B7ZAQ62.51.440---
ADAM176868 / P7853620.160.0590.720
CYP4F1157834 / Q9HBI620.31050.770
AMFR267 / Q9UKV520.6104.51.380
CYBA1535 / P1349821.860---
HADHB3032 / P5508426.120---
AGTRAP57085 / Q6RW1323.350---
IMPA13612 / P2921822.040---
SSR46748 / P5157128.670---
CDIPT10423 / O1473522.210---
SLC35F654978 / Q8N35722.420---
TMEM16555858 / Q9HC0722.60---
MCU90550 / Q8NE8622.040---
MPZL19019 / O9529722.480---
MT-CYB4519 / P0015627.430---
LPCAT310162 / Q6P1A223.250---
HLA-A3105 / P0443921.760---
RP26102 / O7569523.470---
PCDHB1356123 / Q9Y5F0217.330---
DNAJC164215 / Q96KC81.50.190.0760.750
SLC39A1057181 / Q9ULF510.530.131.590
P4HB5034 / P07237---11.51.230
DNAJB1254788 / Q9NXW2---51.660
HERPUD19709 / Q15011---410.40
HSP90B17184 / P14625---15.51.390
TXNL19352 / O43396---19.53.240
UBXN87993 / O00124---30.70
CKAP410970 / Q07065---131.080
SPCS29789 / Q15005---52.80
UBE2J151465 / Q9Y385---5.52.120
DHRS751635 / Q9Y394---60.770
EMC756851 / Q9NPA0---91.940
CCDC4757003 / Q96A33---172.10
SERPINB1289777 / Q96P63---2.55.420
WDR72256764 / Q3MJ13---111.220
GANAB23193 / Q14697---9.51.130
ERO1A30001 / Q96HE7---101.880
UGGT156886 / Q9NYU2---391.660
PIGO84720 / Q8TEQ8---15.52.240
SPTLC110558 / O15269---30.440