Identifier
ORF6

Gene
ORF6
Protein name
ORF6 protein
Localization
ER, Golgi
Uniprot
Description

Disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus. Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities. (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEID
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

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Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

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Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
TRIP119321 / Q15643289.55.8402304.640
SEC24B10427 / O954871128.490866.520
SEC23IP11196 / Q9Y6Y895.678.46060.175.320.16
SEC24A10802 / O9548692.8312.29063.838.450
PDXDC123042 / Q6P99690.922.97050.421.650
NUP984928 / P5294881.589.440.16134.0815.510
PSMC35702 / P1798080.2510.63016.752.220.52
LEMD323592 / Q9Y2U876.52.11059.51.640
GOLGA59950 / Q8TBA676.424.31037.922.140.01
GOLGA22801 / Q0837973.176033.172.720.01
ABCD35825 / P2828866.2535.52037.7520.240
PSMD15707 / Q9946063.676.9017.171.860.21
ITGB13688 / P0555661.921.08039.420.690.1
GBF18729 / Q9253861.424.67061.924.710
ITGB53693 / P18084593.510211.250
PICALM8301 / Q1349255.259.1806.751.120.56
KIF113832 / P5273251.521.95091.5390
CLTC1213 / Q0061050.081.45046.581.350
VPS13B157680 / Q7Z7G8503.95041.53.270
SEC31A22872 / O9497949.8321.72019.838.640.1
ANKLE223141 / Q86XL347.581.23022.580.580.39
USO18615 / O6076346.087.94030.085.180
SEC22B9554 / O7539641.172.83029.672.040
ARCN1372 / P4844440.584.49026.582.940.19
CEMIP223670 / Q9UHN639.751.52026.2510
NUMB8650 / P4975738.59.58071.740.37
ATP2A2488 / P1661535.671.07020.170.60
ANO6196527 / Q4KMQ234.171.54025.171.130
FAT12195 / Q1451732.51.670291.490
COPA1314 / P5362132.251.760.0114.750.80.39
SCYL157410 / Q96KG931.585.04022.083.520
STX56811 / Q1319029.082.84019.581.920
SCFD123256 / Q8WVM828.173.17017.671.990
EMD2010 / P5040225.921.710.0112.920.850.38
GORASP226003 / Q9H8Y824.53.59021.53.150
AP2M11173 / Q96CW1242.9507.50.920
SEC24C9632 / P53992247.66092.870
EPN222905 / O952082410.9503.51.60.32
NUP4211097 / O1550423.258.14042.2514.790
DAB21601 / P9808223.0827.10---
DDX219188 / Q9NR30231.220251.330
AUP1550 / Q9Y67922.51.04014.50.670.01
RPS36188 / P2339622.331.47015.331.010
OSMR9180 / Q9965021.51.81012.51.060
CCDC2228952 / O6082621.42Infinity047.42Infinity0
VEZT55591 / Q9HBM021.251.04010.750.530.16
SLC30A655676 / Q6NXT420.834.06012.832.50.01
IGF2R3482 / P1171720.330.7013.830.480.03
WWOX51741 / Q9NZC7202.97091.340
GOSR19527 / O95249193.6309.51.820
RHBDD325807 / Q9Y3P4188.75014.57.050
TRAPPC822878 / Q9Y2L517.537.920---
NDC155706 / Q9BTX117.421.19015.421.050
ACBD591452 / Q5T8D3172.40152.120
COG425839 / Q9H9E316.756.609.253.640.17
ARFGAP326286 / Q9NP6116.583.7708.581.950.16
POM121C100101267 / A8CG3416.585.25032.0810.160
LGR455366 / Q9BXB116.331.46014.331.280
SLC12A26558 / P5501115.830.9905.330.330.19
RAB1A5861 / P6282015.831.6014.331.450.01
STOM2040 / P2710515.171.9011.171.40
RUNDC1146923 / Q96C3414.513.96032.531.30
BMP2K55589 / Q9NSY114.3326.330---
GULP151454 / Q9UBP914.2511.670---
ABCC14363 / P33527140.706.50.320
RHBDD257414 / Q6NTF9142.940112.310
MCM54174 / P3399213.51.09014.51.170
VRK27444 / Q86Y0713.080.72010.080.550
SLC35E179939 / Q96K371310.5606.55.280
RAB1B81876 / Q9H0U412.51.550141.730
ACSL32181 / O9557312.50.9208.50.630
AGFG23268 / O9508112.572.220---
STBD18987 / O9521012.331.1505.830.540.01
MBOAT779143 / Q96N6612.331.2905.330.560.01
FSCN16624 / Q1665812.081.020.0112.081.020.01
MCM3AP8888 / O6031812.0825.01081.58168.880
RCC255920 / Q9P258121.33080.890
CAD790 / P2770811.831.1908.830.890
COPB29276 / P3560611.831.3608.330.960
ARF4378 / P1808511.52.16061.130
ZDHHC1354503 / Q8IUH411.54.01020.70.05
CES11066 / P2314111.081.0306.580.610.01
DDX39B7919 / Q13838111.590101.440
HOOK384376 / Q86VS8115.3073.370
ARF1375 / P8407710.671.510.015.170.730.2
CISD2493856 / Q8N5K110.581.010.018.080.770.17
DHCR71717 / Q9UBM710.51.7404.50.750
RPN16184 / P0484310.51.38070.920
ACBD364746 / Q9H3P710.52.2903.50.760
GRAMD1A57655 / Q96CP6101.37040.550
GLG12734 / Q92896101.21080.970
STIM257620 / Q9P246100.85050.420
YIPF325844 / Q9GZM5104.304.51.930
TOR1AIP126092 / Q5JTV8101.02012.51.270
RPN26185 / P048449.920.830.0113.421.120
PAFAH1B15048 / P430349.671.0408.170.880.01
NUP589818 / Q9BVL29.67Infinity022.17Infinity0
NUP1559631 / O756949.581.04012.081.320
PRKDC5591 / P785279.52.570.2926.57.180
COG222796 / Q147469.58.9806.56.150
SLC4A26522 / P049209.50.8702.50.230.05
COG383548 / Q96JB29.510.9801.51.730.07
COPG226958 / Q9UBF29.2521.380---
NUP6223636 / P371989.0816.60.4125.5846.770
RAE18480 / P784069Infinity09Infinity0
PTPN15770 / P180318.750.870.017.250.720.01
SREBF26721 / Q127728.50.65040.310
SLC12A46560 / Q9UP958.51.32010.150.1
DENND1A57706 / Q8TEH38.5Infinity0---
PTGR122949 / Q149148.331.1202.830.380.02
DARS11615 / P148688.331.208.831.270
YKT610652 / O154988.251.210.015.250.770.01
FADS29415 / O958648.171.040.013.670.470.23
CLEC16A23274 / Q2KHT3810.6706.58.670
DHRS39249 / O7591181.1304.50.630
TEX26451368 / Q9Y6I980.807.50.750
SPINT210653 / O4329181.5205.51.050
VAPA9218 / Q9P0L081.0405.50.720
RIC157589 / Q4ADV781.45010.180.1
RAB8A4218 / P6100681.67040.840.04
NETO281831 / Q8NC677.50.9404.50.570
RAB3511021 / Q152867.51.120.018.51.270.01
RAB8B51762 / Q929307.51.8808.52.130
TECR9524 / Q9NZ017.331.1206.330.970
NUP35129401 / Q8NFH57.081.910.0116.584.480
BLZF18548 / Q9H2G973.08041.760
TMEM15957146 / Q96B9679.104.55.850
RABL3285282 / Q5HYI871.85092.380
STT3B201595 / Q8TCJ270.5105.50.40
PRMT13276 / Q9987371.17071.170
ATP2B1490 / P2002070.8906.50.820
VANGL181839 / Q8TAA976.390---
RPL266154 / P612546.921.020.015.920.870.1
GOPC57120 / Q9HD266.830.520.01---
MTFR19650 / Q153906.674.210.1912.6780
RPS246229 / P628476.52.41041.490
TFRC7037 / P027866.51.11071.190
LRP64040 / O755816.50.97030.450
PSMD45710 / P550366.55.73032.640
EIF2S11965 / P051986.51.1506.51.150
BET110282 / O151556.51.53061.410
CKAP410970 / Q070656.50.5307.50.610
NAA2580018 / Q14CX76.5Infinity05Infinity0
SLC1A56510 / Q157586.51.3604.50.940
SMPD455627 / Q9NXE46.51.06040.650
POR5447 / P164356.250.460.016.750.50.01
RPL76129 / P181246.250.940.017.251.10.01
SRC6714 / P129316.250.940.016.751.020.01
ITSN250618 / Q9NZM36.1733.140.01---
VAPB9217 / O952926.080.670.027.080.780.01
USP149097 / P545786.08146.370.01---
REEP57905 / Q0076563010.50.1
BET1L51272 / Q9NYM962.79052.320
RAB1451552 / P6110661.206.51.310
SREBF16720 / P3695660.4901.50.120.07
RPL216144 / P4677861.2010.20.1
TMEM13123505 / Q925455.830.660.014.330.490.01
DDRGK165992 / Q96HY65.670.8600.670.10.22
CENPH64946 / Q9H3R55.5830.10.027.5840.890.01
RAB11A8766 / P624915.53.7604.53.080
GPAT384803 / Q53EU65.50.8702.50.40
PEX135194 / Q929685.56.5010.512.410
RER111079 / O152585.52.72062.970
SEC24D9871 / O948555.58.410913.760
TMEM3355161 / P570885.51.22051.110
TMEM20984928 / Q96SK25.50.9605.50.960
EPHA21969 / P293175.50.82081.20
AAAS8086 / Q9NRG95.51.3403.50.850
TYW155253 / Q9NV665.50.59030.320.04
HM1381502 / Q8TCT95.51.1504.50.940
SCD6319 / O007675.51.62020.590.05
FNDC3A22862 / Q9Y2H65.50.60---
HIP1R9026 / O751465.51430---
MKS154903 / Q9NXB05.251.920.012.7510.15
ARL6IP510550 / O759155.080.990.026.581.280.01
RPL306156 / P6288851.503.51.050
TMEM21454867 / Q6NUQ450.55020.220.05
GPR89A653519 / B7ZAQ653.0603.52.140
SLC33A19197 / O0040051.69010.340.1
CLPTM11209 / O9600550.57050.570
SCAMP19522 / O1512651.3803.50.960
SMU155234 / Q2TAY751.0304.50.920
PRR1155771 / Q96HE951.21020.480.05
TM9SF356889 / Q9HD4551.1705.51.280
CDC42998 / P6095351.2104.51.090
PSMB55693 / P2807450.9303.50.650
ACOT711332 / O0015450.91061.090
TMEM205374882 / Q6UW6851.82010.360.1
EMC756851 / Q9NPA051.0401.50.310.07
CYP51A11595 / Q1685050.280---
RPS76201 / P620814.671.250.014.171.110.02
CDKAL154901 / Q5VV424.580.390.036.080.520.01
RPL7A6130 / P624244.50.530.166.50.760.01
RPL18A6142 / Q025434.50.74050.820
ABCG29429 / Q9UNQ04.51.0202.50.570
FURIN5045 / P099584.51.3803.51.080
ADAM98754 / Q134434.50.705.50.860
USP3323032 / Q8TEY74.50.75020.330.05
WDR1857418 / Q9BV384.51.49030.990
RPL35A6165 / P180774.51.41020.630
FAF223197 / Q96CS34.51.28020.570.05
RAC15879 / P630004.51.46020.650.05
SMAP264744 / Q8WU794.5130---
LDLRAP126119 / Q5SW964.5Infinity0---
MFF56947 / Q9GZY84.253.050.2410.257.350.01
RPL27A6157 / P467764.171.010.013.670.890.03
RPL136137 / P263734.170.930.014.170.930.02
NUP939688 / Q8N1F74.172.390.2410.175.830.01
CCDC138165055 / Q96M894.081.390.2315.585.290
LCLAT1253558 / Q6UWP741.0502.50.650
BUB39184 / O4368441.11030.830
SLC7A1123657 / Q9UPY540.9601.50.360.07
UBXN423190 / Q9257540.61030.460
TM9SF49777 / Q9254441.1703.51.020
SLC30A564924 / Q8TAD443.5902.52.240
PIGU128869 / Q9H49041.1403.510
ABCC21244 / Q9288740.4303.50.380
DYNC1I21781 / Q1340941.08020.540.05
SEC23A10484 / Q1543641.0304.51.160
HADHA3030 / P409393.830.640.0110.331.740
RPS66194 / P627533.830.910.014.831.150.01
ARPC1B10095 / O151433.830.690.014.830.870.01
CISD155847 / Q9NZ453.832.290.013.331.990.01
TMX251075 / Q9Y3203.50.72020.410
IFT2090410 / Q8IY313.5Infinity01Infinity0.1
RAB7A7879 / P511493.51.1404.51.470
UBXN87993 / O001243.50.82010.240.1
ZMPSTE2410269 / O758443.50.99020.570.05
FKBP823770 / Q143183.50.7904.51.020
RAB2123011 / Q9UL253.52.07010.590.1
HSD17B1151170 / Q8NBQ53.51.08020.620.05
RAB2A5862 / P610193.50.9901.50.420.07
STT3A3703 / P469773.50.59030.50
PLIN2123 / Q995413.5Infinity0---
TMED8283578 / Q6PL243.51.140---
SAR1A56681 / Q9NR313.50.850---
UBR423352 / Q5T4S73.56.280---
ABCC38714 / O154383.330.450.01---
DLD1738 / P096223.250.530.2413.752.260.01
ALDOA226 / P040753.250.740.166.251.420.01
RPL96133 / P3296930.8101.50.410.07
RPL239349 / P6282930.99041.320
MYADM91663 / Q96S9731.28031.280
SLC39A1423516 / Q1504331.3201.50.660.07
SUN123353 / O9490130.3504.50.520
DAG11605 / Q1411832010.670.1
SNRPD16632 / P6231430.8302.50.70
PI4K2B55300 / Q8TCG2319.504.529.250
PCDH95101 / Q9HC5630.72010.240.1
WDR72256764 / Q3MJ1330.32020.210.05
YIPF581555 / Q969M333.1201.51.560.07
LRIG3121227 / Q6UXM130.58040.780
SOAT16646 / P3561030.59040.790
GOSR29570 / O1465333.1204.54.680
MICAL29645 / O9485130.55020.370
SLC25A101468 / Q9UBX332010.670.1
CYP4F1157834 / Q9HBI630.460---
CANT1124583 / Q8WVQ135.380---
SCAMP310067 / O1482830.850---
DPP991039 / Q86TI230.810---
EPHX12052 / P0709930.440---
PLD323646 / Q8IV082.51.14020.910.05
TMEM201199953 / Q5SNT22.50.803.51.120
SERPINH1871 / P504542.50.53030.640.04
DDB11642 / Q165312.50.52081.650
LMAN13998 / P492572.51.9704.53.550
NNT23530 / Q134232.50.47020.380.05
TTC379652 / Q6PGP72.51.430.2184.570.01
ATP5F1A498 / P257052.51.510.0584.840
C17orf8055028 / Q9BSJ52.51.6906.54.390
ABCC410257 / O154392.50.3020.240
TOR1AIP2163590 / Q8NFQ82.50.650---
RPL126136 / P300502.51.530---
CPT1A1374 / P504162.51.020---
S1PR31903 / Q995002.52.890---
ATP1A1476 / P050232.50.420---
TMX181542 / Q9H3N12.50.610---
GDI22665 / P503952.420.670.258.422.330.01
NPC14864 / O1511820.420.053.50.740
CALCOCO157658 / Q9P1Z2210.401.57.80.07
ARL8B55207 / Q9NVJ220.9202.51.150
YIF1A10897 / O9507023.5903.56.280
TMTC3160418 / Q6ZXV520.170.053.50.30
ADGRG657211 / Q86SQ420.33020.330.05
AMIGO2347902 / Q86SJ220.320.0540.650
SEC136396 / P5573521.0602.51.330
DNAJC164215 / Q96KC820.25020.250
CHP111261 / Q9965320.8101.50.60.07
TMEM24523731 / Q9H33021.35010.680.1
RNF149284996 / Q8NC4220.670---
TMED210959 / Q1536321.680---
AMFR267 / Q9UKV520.590---
PCDHB1356123 / Q9Y5F0217.330---
APPL255198 / Q8NEU81.920.490.3114.423.680.01
CDK5RAP255755 / Q96SN81.920.50.2116.424.240
RPS96203 / P467811.830.470.163.830.980.01
PRMT510419 / O147441.50.420.0741.120
TRAM123471 / Q156291.50.270.0750.890
VAC1455697 / Q08AM61.52.60.0735.20
NCEH157552 / Q6PIU21.50.40.074.51.190
EIF63692 / P565371.51.10.0721.460
LMNB14001 / P207001.50.240.075.50.880
OFD18481 / O756651.330.690.3510.835.650.01
AKAP910142 / Q999961.331.150.1713.3311.50
SLC26A21836 / P5044310.580.12.51.460
VPS13A23230 / Q96RL710.50.13.51.730
PEX195824 / P408551Infinity0.16Infinity0
SDHA6389 / P3104010.350.13.51.210
MPDU19526 / O7535210.670.1320
AQR9716 / O6030615.780.1317.330
SNX19399979 / Q9254310.240.130.720
VKORC1L1154807 / Q8N0U810.60.12.51.510
CYB5A1528 / P0016710.260.13.50.920
EBAG99166 / O00559120.12.550
SLC30A7148867 / Q8NEW014.330.12.510.830
ACOT923597 / Q9Y3050.830.180.1811.332.430
NUP18823511 / Q5SRE50.831.040.189.3311.660
GLE12733 / Q53GS70.831.010.3327.8333.950
ALAS1211 / P13196---6.53.520
PPIB5479 / P23284---2.50.660
ATP5F1C509 / P36542---34.460
ODF2L57489 / Q9ULJ1---3.5910
HSD17B103028 / Q99714---33.390
GRSF12926 / Q12849---5.171.220.01
CPS11373 / P31327---2.51.30
ZDHHC351304 / Q9NYG2---22.670
NDUFS24720 / O75306---4.53.60
GGCT79017 / O75223---22.170
CA12771 / O43570---2.51.270
GLS2744 / O94925---19.175.110
MIGA1374986 / Q8NAN2---37.80
COX5B1329 / P10606---54.260
DBT1629 / P11182---7.53.10
KPNB13837 / Q14974---6780
SGTA6449 / O43765---45.070
XPO17514 / O14980---5.595.330
SUCLA28803 / Q9P2R7---5.52.920
MTRF19617 / O75570---34.730
TXNL19352 / O43396---233.910
DDOST1650 / P39656---20.90
MDH24191 / P40926---5.53.450
PCNT5116 / O95613---537.140
TIMM4410469 / O43615---13.753.50
CLPX10845 / O76031---8.671.790.01
CEP25011190 / Q9BV73---10Infinity0
APPL126060 / Q9UKG1---2.52.280
MYCBP223077 / O75592---115.5250.250
ANGEL123357 / Q9UNK9---2.50.770
NBAS51594 / A2RRP1---4.52.720
ERGIC351614 / Q9Y282---43.710
CDK5RAP151654 / Q96SZ6---43.410
NUP5453371 / Q7Z3B4---9.5Infinity0
TRMT10C54931 / Q7L0Y3---63.390
CEP7255722 / Q9P209---5.335.660.01
PI4K2A55361 / Q9BTU6---29.450
TTC7A57217 / Q9ULT0---511.30
NDUFV24729 / P19404---6.54.630
NDUFV34731 / P56181---6.333.250
IPO479711 / Q8TEX9---12.8315.410
GFM185476 / Q96RP9---6.52.660
WDR7584128 / Q8IWA0---21.020
MRPL4584311 / Q9BRJ2---4.55.20
PNPT187178 / Q8TCS8---27.332.880.01
HAUS1115106 / Q96CS2---6.5Infinity0
SPRYD4283377 / Q8WW59---2.55.20
ETFA2108 / P13804---9.922.730.01
DYNLL18655 / P63167---21.650
TDRKH11022 / Q9Y2W6---33.060
NADK2133686 / Q4G0N4---64.660
VDAC37419 / Q9Y277---31.370
PHB211331 / Q99623---55.10
SHMT26472 / P34897---14.756.020
NDUFS14719 / P28331---15.582.340
PNPLA850640 / Q9NP80---7.335.580.01
POM1219883 / Q96HA1---33.5814.740
ITPR33710 / Q14573---2.50.150
NXF110482 / Q9UBU9---16.553.630
YME1L110730 / Q96TA2---4.52.210
PRORP9692 / O15091---14.084.90
ANAPC551433 / Q9UJX4---4.533.430
DDX19A55308 / Q9NUU7---6.515.360
LRPPRC10128 / P42704---213.590
GTPBP1085865 / A4D1E9---3.53.870
SLC38A254407 / Q96QD8---21.460
LYRM790624 / Q5U5X0---314.180
YIF1B90522 / Q5BJH7---21.960
ACAD928976 / Q9H845---2.55.20
GPAT4137964 / Q86UL3---20.510
ERAL126284 / O75616---2.52.770
MGME192667 / Q9BQP7---2.55.420
PREB10113 / Q9HCU5---20.720