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Identifier
ORF9B

Gene
ORF9b
Protein name
ORF9b protein
Localization
mitochondrion
Uniprot
P0DTD2
Description

Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

Options

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Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

Options

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Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
ATP5F1B506 / P0657685.8332.36040.3315.210
AKAP18165 / Q9266785.1776.25052.6747.160
MAVS57506 / Q7Z4346634.67052.527.580
MARK22011 / Q7KZI761.515990389880
PPM1B5495 / O7568844.33300.93014.83100.670
HSPA93313 / P3864642.3321.39055.3327.960
EXD255218 / Q9NVH041.42137.36031.92105.860
HKDC180201 / Q2TB9041Infinity015Infinity0
TUFM7284 / P494113969.93020.536.760
MTR4548 / Q9970738.256.7701.250.220.53
CYP24A11591 / Q0797336.675.240.0160.678.660
ENO12023 / P0673334.929.206.421.690.44
GPD22820 / P4330433Infinity021Infinity0
ALDH2217 / P0509132.5563.33022381.330
TOMM709868 / O9482630.5Infinity018Infinity0
AIFM19131 / O9583130.529.9201918.640
MFF56947 / Q9GZY828.2540.25019.2527.420
MTFR19650 / Q1539028.1728.5025.6725.970
SMC1A8243 / Q1468327.510.750---
DLD1738 / P0962227.255.02030.755.660
HADHA3030 / P4093926.835.12028.835.50
MTCL123255 / Q9Y4B526.3316.99013.838.920.01
SDHA6389 / P310402612.880199.410
MYO1980179 / Q96H5525.9220.66033.4226.640
TDRKH11022 / Q9Y2W625.5221023199.330
GLUD12746 / P0036724.598025.51020
POLR3A11128 / O1480224.54.720---
HK13098 / P19367246240123120
MTFR1L56181 / Q9H01923.8340.5018.3331.150
CAD790 / P2770823.332.4700.830.090.18
DDB11642 / Q1653122.55.25010.230.1
APPL255198 / Q8NEU821.926.0400.420.120.34
ATP5F1A498 / P2570520.520.11024.524.040
CPS11373 / P3132720.522.6802932.090
MCM74176 / P3399320.176.810000.43
ARMCX351566 / Q9UH62202080101040
RBBP75931 / Q1657619.8310.860---
PCCB5096 / P0516619.674.750.1726.676.450.01
AARS116 / P4958819.4212.990000.62
OCIAD154940 / Q9NX401947.05018.545.810
MCL14170 / Q0782018Infinity09Infinity0
MARK34140 / P2744818Infinity0---
CISD155847 / Q9NZ4517.8315.73013.8312.20
CDK5RAP255755 / Q96SN816.924.390---
PFAS5198 / O1506716.587.10---
PSMC15700 / P6219116.53.490---
ALDH3A2224 / P5164816.171.1805.670.410.23
EIF2S31968 / P4109116.081.8500.580.070.39
HSPD13329 / P10809161.340.4960.55.080
FDXR2232 / P22570162080151950
SLC25A1310165 / Q9UJS0164160---
MTHFD14522 / P1158615.5821.830.010.080.110.41
RBBP45928 / Q0902815.514.140---
MTARC254996 / Q969Z314.5Infinity08.5Infinity0
DPP991039 / Q86TI214.54.460---
TRAP110131 / Q1293114.421.980.1760.428.30
GSR2936 / P0039014.172.5703.170.580.3
POLRMT5442 / O0041113.5Infinity022Infinity0
RHOT289941 / Q8IXI113.5234012.5216.670
SND127044 / Q7KZF413.55.010---
ME14199 / P4816311.83220---
ALDH3B1221 / P4335311.757.7802.751.820.3
SAMM5025813 / Q9Y51211.599.6704.5390
MFN29927 / O9514011.5Infinity03Infinity0
GOT22806 / P0050511Infinity01.5Infinity0.07
QARS15859 / P4789710.75130---
NDUFS14719 / P2833110.582.080.0156.08110
FKBP823770 / Q1431810.52.5207.51.80
USP3084749 / Q70CQ310.5Infinity08.5Infinity0
ATAD184896 / Q8NBU510.528.740924.630
PNPT187178 / Q8TCS810.331.320.2770.338.970
BCL2L1323786 / Q9BXK510Infinity09.5Infinity0
UBA17317 / P223149.8310.890.01---
IREB23658 / P482009.8315.060---
CPNE18904 / Q998299.674.750---
YME1L110730 / Q96TA29.55.15063.250
TRABD80305 / Q9H4I39.5Infinity02Infinity0
NDUFS24720 / O75306914.18020.532.30
ANGEL123357 / Q9UNK993.0206.52.180
ALPK2115701 / Q86TB3911703.545.50
ARMC1083787 / Q8N2F69Infinity03Infinity0
ATP2A2488 / P166158.670.250.012.170.060.17
ME24200 / P233688.5Infinity013Infinity0
ELAC260528 / Q9BQ528.428.890.1618.9219.980
MED13L23389 / Q71F568.428.330.01---
SHMT26472 / P348978.254.110.0126.2513.060
MFN155669 / Q8IWA48Infinity06Infinity0
OAT4942 / P041818Infinity04Infinity0
DLST1743 / P3695785206.542.250
DNM11759 / Q051937.7516.450.01---
VAT110493 / Q995367.674.901.671.070.21
FBXL426235 / Q9UKA27.5Infinity02.5Infinity0
PRKAR2A5576 / P138617.5Infinity0---
GNAS2778 / O954677.335.6100.830.640.18
RHOT155288 / Q8IXI2772.803.536.40
ALDH1B1219 / P308377Infinity09.5Infinity0
RMDN2151393 / Q96LZ7720.220720.220
ETFA2108 / P138046.922.20.0222.427.110
NHLRC2374354 / Q8NBF26.836.20---
ALDOA226 / P040756.751.540.010.750.170.19
NUP1559631 / O756946.580.70.012.080.220.21
MIGA1374986 / Q8NAN26.556.3301086.670
DHRS39249 / O7591160.84040.560
USP118237 / P517845.8310.010.01---
TOMM2256993 / Q9NS695.5260418.910
NPEPPS9520 / P557865.54.77010.870.1
PON25445 / Q151655.58.940---
ASMTL8623 / O956715.335.740.01---
PTPN15770 / P180315.250.520.014.750.470.01
UCHL17345 / P09936518.570---
DSTN11034 / P6098156.840---
PHB5245 / P352324.8312.170.011.834.610.16
DRG14733 / Q9Y2954.8315.720.01---
TRAK266008 / O602964.521.270523.640
MCCC264087 / Q9HCC04.529.2509.561.750
GFM185476 / Q96RP94.52.5402413.570
UBA655236 / A0AVT14.511.70---
POLR2C5432 / P193874.529.250---
NDUFA104705 / O952994.421.510.217.425.960
DNAJA13301 / P316894.255.140.01---
GLS2744 / O949254.171.380.2438.1712.640
USP3323032 / Q8TEY740.6602.50.410
DNAJC1155735 / Q9NVH142.8902.51.810
TOMM5401505 / Q8N4H54Infinity04Infinity0
MCM884515 / Q9UJA3413.870---
RRM16240 / P239213.8312.20.01---
MDH24191 / P409263.53.7902324.920
FOXRED155572 / Q96CU93.5Infinity04.5Infinity0
GDAP154332 / Q8TB363.5Infinity08Infinity0
KARS13735 / Q150463.5Infinity01.5Infinity0.07
RAB11A8766 / P624913.52.28010.650.1
VPS13A23230 / Q96RL73.51.730---
CAPN2824 / P176553.530.330---
NAT926151 / Q9BTE03.5Infinity0---
LPIN364900 / Q9BQK83.5260---
GNPDA110007 / P469263.512.130---
LACTB114294 / P831113.5Infinity0---
IMPDH23615 / P122683.5Infinity0---
PDE8A5151 / O606583.53.790---
CALCOCO157658 / Q9P1Z23.5260---
HERC426091 / Q5GLZ83.5260---
TIMM5092609 / Q3ZCQ83Infinity03.5Infinity0
DLAT1737 / P105153Infinity0.045.5Infinity0
PLD6201164 / Q8N2A83Infinity02Infinity0
MTX3345778 / Q5HYI73Infinity03Infinity0
AAAS8086 / Q9NRG930.7102.50.590
NPAT4863 / Q1420735.030---
EIF2S11965 / P0519830.520---
PRR1155771 / Q96HE930.710---
PCK25106 / Q168222.5Infinity03Infinity0
LRPPRC10128 / P427042.50.740.385.525.410
KLHDC7A127707 / Q5VTJ32.5Infinity01Infinity0.1
MAN2C14123 / Q9NTJ42.59.290---
AIP9049 / O001702.55.20---
OPA14976 / O603132.5Infinity0---
WDR72256764 / Q3MJ132.50.270---
FAM171A2284069 / A8MVW02.57.650---
FUNDC265991 / Q9BWH22.5Infinity0---
YARS18565 / P545772.5Infinity0---
NDUFA94704 / Q16795240480
TOMM209804 / Q153882Infinity0.055Infinity0
FEM1B10116 / Q9UK732Infinity0.052.5Infinity0
MRPS3010884 / Q9NP9225208.52210
NLN57486 / Q9BYT82Infinity0---
TTC47268 / O9580121.010---
POLR1B84172 / Q9H9Y626.50---
ABCB722 / O750271.51.130.074.53.390
AFG3L210939 / Q9Y4W61.5Infinity0.076Infinity0
FASTKD560493 / Q7L8L61.420.990.2729.4220.430
MTIF24528 / P46199117.330.116277.330
ALDH18A15832 / P5488618.670.125.52210
MTFR2113115 / Q6P4441Infinity0.12.5Infinity0
ALDH7A1501 / P494191Infinity0.12Infinity0
PDHA15160 / P0855914.330.110.545.50
PTCD355037 / Q96EY7000.5460.176.430
ACADVL37 / P49748---13.5780
FH2271 / P07954---19.6711.230
MMUT4594 / P22033---3Infinity0
ALAS1211 / P13196---22.518.280
BCKDHA593 / P12694---7.59.750
CRAT1384 / P43155---2.5Infinity0
PDHB5162 / P11177---4Infinity0
PUS180324 / Q9Y606---5.5Infinity0
AK4205 / P27144---2Infinity0
ACOT923597 / Q9Y305---29.337.40
BCS1L617 / Q9Y276---736.40
EARS2124454 / Q5JPH6---3Infinity0
POLG5428 / P54098---4.5Infinity0
NT5DC264943 / Q9H857---4.5Infinity0
DNAJA39093 / Q96EY1---5.5Infinity0
FASTKD222868 / Q9NYY8---815.410
ACAD1080724 / Q6JQN1---8Infinity0
COQ8B79934 / Q96D53---5.5Infinity0
ECI210455 / O75521---4.5Infinity0
VARS257176 / Q5ST30---2.5Infinity0
TRMT2B79979 / Q96GJ1---3.5910
HSDL284263 / Q6YN16---6780
C1QBP708 / Q07021---2.5Infinity0
PITRM110531 / Q5JRX3---5520
SPATA2064847 / Q8TB22---4Infinity0
DECR11666 / Q16698---6.5Infinity0
ECH11891 / Q13011---6390
MRPL583396 / Q14197---3Infinity0
COX5B1329 / P10606---13.515.950
DBT1629 / P11182---25.514.730
NDUFA64700 / P56556---3780
SDHB6390 / P21912---7Infinity0
SUPV3L16832 / Q8IYB8---112860
UQCRC27385 / P22695---4Infinity0
SUCLA28803 / Q9P2R7---23.519.710
CS1431 / O75390---5Infinity0
ECHS11892 / P30084---1037.140
PMPCB9512 / O75439---2.5Infinity0
MTRF19617 / O75570---1133.650
NDUFS34722 / O75489---6Infinity0
LONP19361 / P36776---2Infinity0
NDUFB94715 / Q9Y6M9---3Infinity0
NME44833 / O00746---6.584.50
OXA1L5018 / Q15070---4.54.50
ERAL126284 / O75616---1858.50
UQCRFS17386 / P47985---5.571.50
TIMM4410469 / O43615---35.2511.390
CLPX10845 / O76031---38.1710.30
PRDX310935 / P30048---6.515.360
PYCR15831 / P32322---112860
MRPL311222 / P09001---29.450
LETM13954 / O95202---12.51300
MRPS2828957 / Q9Y2Q9---841.60
ACAD928976 / Q9H845---12.51300
NDUFAF429078 / Q9P032---8.540.180
ISCU23479 / Q9H1K1---15.6713.960
HIBCH26275 / Q6NVY1---2Infinity0
MRPL199801 / P49406---4.5Infinity0
DHX3022907 / Q7L2E3---1618.910
POLDIP226073 / Q9Y2S7---8.563.140
MRPS1751373 / Q9Y2R5---4160
MRPS251116 / Q9Y399---3390
MRPL4851642 / Q96GC5---8Infinity0
MRPS2351649 / Q9Y3D9---3.5Infinity0
CDK5RAP151654 / Q96SZ6---1828.360
TACO151204 / Q9BSH4---4.51170
MRPL3751253 / Q9BZE1---7Infinity0
COQ351805 / Q9NZJ6---2.5650
TRMT10C54931 / Q7L0Y3---2422.290
TRMT61B55006 / Q9BVS5---3Infinity0
PDPR55066 / Q8NCN5---8Infinity0
DARS255157 / Q6PI48---6.519.880
MRM355178 / Q9HC36---4Infinity0
DHTKD155526 / Q96HY7---2Infinity0
SDHAF357001 / Q9NRP4---6Infinity0
MRPS2256945 / P82650---7.5Infinity0
RARS257038 / Q5T160---8.5Infinity0
AARS257505 / Q5JTZ9---6.5Infinity0
NDUFV24729 / P19404---17170
TFB2M64216 / Q9H5Q4---2.5Infinity0
MRPL4465080 / Q9H9J2---10650
MRPL2479590 / Q96A35---112860
TEFM79736 / Q96QE5---3Infinity0
MRPS564969 / P82675---1269.330
MRPS2464951 / Q96EL2---5.531.780
NOA184273 / Q8NC60---5.595.330
MRPL4584311 / Q9BRJ2---12.522.410
MRPS3692259 / P82909---5Infinity0
MGME192667 / Q9BQP7---12124.80
NDUFAF291942 / Q8N183---5.5Infinity0
PDE12201626 / Q6L8Q7---4Infinity0
LYRM790624 / Q5U5X0---4.529.250
MRPS964965 / P82933---6.528.170
SPRYD4283377 / Q8WW59---10.560.670
ATP5F1C509 / P36542---920.350
ALDH1L2160428 / Q3SY69---25Infinity0
ACOT210965 / P49753---71.58.980
NADK2133686 / Q4G0N4---19.525.350
C17orf8055028 / Q9BSJ5---1614.340
PHB211331 / Q99623---7.58.480
MTHFD1L25902 / Q6UB35---25.5120.550
PNPLA850640 / Q9NP80---18.8321.620
TBRG49238 / Q969Z0---3.5Infinity0
GRSF12926 / Q12849---29.679.020
OGDH4967 / Q02218---8Infinity0
SUCLG28801 / Q96I99---13Infinity0
HSD17B103028 / Q99714---13260
TSFM10102 / P43897---9.5Infinity0
ATP5PD10476 / O75947---5.33Infinity0.01
IDH3B3420 / O43837---5Infinity0
HARS223438 / P49590---4Infinity0
PRORP9692 / O15091---31.0814.020
VWA823078 / A3KMH1---70191.580
GSTK1373156 / Q9Y2Q3---5Infinity0
AK350808 / Q9UIJ7---3.5Infinity0
NDUFV34731 / P56181---21.8316.150
MRPS3560488 / P82673---17.547.890
ATPAF164756 / Q5TC12---4Infinity0
NDUFAF579133 / Q5TEU4---9.554.890
GTPBP1085865 / A4D1E9---1637.820
PTPMT1114971 / Q8WUK0---5.540.860
PPA227068 / Q9H2U2---7Infinity0
ACSF280221 / Q96CM8---4Infinity0
IDH23418 / P48735---2Infinity0
HINT284681 / Q9BX68---2.5Infinity0
CARS279587 / Q9HA77---3Infinity0
PDK35165 / Q15120---3Infinity0
CYB5A1528 / P00167---20.520