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Identifier
S

Gene
S
Protein name
Spike glycoprotein
Localization
cell - ER, Golgi, virus - spike
Uniprot
P0DTC2
Description

Chain S1 attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. Chain S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Chain S2' acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis. (From UniProt)

Information & downloads

Downloads

These downloads are specific to this bait. Full data set downloads can be found on the downloads page.

Sequence

MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
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Visualization

Specificity

Plot the specificity of a prey versus its spectral count. The specificty of a prey is calculated as the fold change in the spectral count relative to the average across all other baits. Any other conditions/treatments for the query bait are ignored when calculating the average. Every other bait can contribute a single value when calculting the average, and this value is the maximum spectral count across any conditions present for that bait.

Orange points have infinite specificty. Hover over a point to see its label or click on a point to add a label to the plot.

Select a condition

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Compare conditions

Compare the spectral counts between two different conditions. Any prey passing the option criteria for at least one bait will be displayed. Hover over a point to see its label or click on a point to add a label to the plot.

Select a pair of conditions

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Preys

Condition legend
  • Ct: C-terminal tag
  • Nt: N-terminal tag
  • SC: spectral counts, calculated as the average spectral count between replicates minus the average detect in controls
  • Spec: specificity, calculated as the fold enrichment of a prey relative to all other bait proteins
  • FDR: false discovery rate
Prey
ID (Entrez / UniProt)ConditionsProfile
C-terminal tag (Ct)N-terminal tag (Nt)
S.C.
Spec.
FDR
S.C.
Spec.
FDR
TRIP119321 / Q1564367.51.160---
ANKLE223141 / Q86XL362.081.620---
ITGB13688 / P0555648.420.840.01000.62
GOPC57120 / Q9HD2641.833.550---
ATP2A2488 / P1661541.671.250---
PDXDC123042 / Q6P99634.921.070---
ANO6196527 / Q4KMQ234.171.5400.170.010.34
VEZT55591 / Q9HBM033.751.690---
CEMIP223670 / Q9UHN632.251.220---
LEMD323592 / Q9Y2U830.50.80---
SLC12A26558 / P5501127.331.750---
SEC22B9554 / O7539624.171.590000.48
ACSL32181 / O95573241.820---
CDKAL154901 / Q5VV4222.582.040---
AUP1550 / Q9Y67922.51.040---
LSG155341 / Q9H08922.081.420.01---
NDC155706 / Q9BTX121.421.480---
POR5447 / P1643521.251.640---
ALDH3A2224 / P5164821.171.570---
GRAMD1B57476 / Q3KR37213.750---
VRK27444 / Q86Y0720.581.150---
ABCC21244 / Q9288720.52.380---
CKAP410970 / Q0706519.51.660---
STBD18987 / O9521019.331.850---
SREBF26721 / Q12772191.50---
DHRS39249 / O75911192.850---
CYP51A11595 / Q16850191.10---
RPS36188 / P2339618.331.190---
ABCC14363 / P3352717.50.880---
SLC4A26522 / P0492017.51.650---
LRRC5955379 / Q96AG417.252.580---
SREBF16720 / P3695616.51.380---
GRAMD1A57655 / Q96CP616.52.340---
DDX219188 / Q9NR3016.50.860---
LGR455366 / Q9BXB116.331.460---
PPP1R9A55607 / Q9ULJ816.17167.50---
CISD2493856 / Q8N5K116.081.5704.580.450.25
STT3B201595 / Q8TCJ2161.2060.450
VAPB9217 / O9529214.581.660---
WDR72256764 / Q3MJ1314.51.640---
TEX26451368 / Q9Y6I914.51.490---
TYW155253 / Q9NV6614.51.610---
PTPN15770 / P1803114.251.450---
STX56811 / Q1319013.581.260---
FKBP823770 / Q1431813.53.330---
PTPRJ5795 / Q1291313.53.440---
EPHA21969 / P2931713.52.080---
CD44960 / P160701324.140---
TRPM754822 / Q96QT4122.150---
STIM257620 / Q9P24611.50.980---
YKT610652 / O1549811.251.670---
VAPA9218 / Q9P0L0111.450---
FNDC3A22862 / Q9Y2H610.51.170---
MBOAT779143 / Q96N6610.331.070---
SRC6714 / P1293110.251.580---
DNAJC164215 / Q96KC8101.270---
TRPM454795 / Q8TD43102.050---
ABCC410257 / O15439101.230---
TMEM21454867 / Q6NUQ49.51.070---
FADS29415 / O958649.171.170.01---
SLC27A410999 / Q6P1M092.820---
ATP7A538 / Q046568.831.390---
STOM2040 / P271058.671.060---
EPHX12052 / P070998.51.30---
MCM54174 / P339928.50.670---
ATP2B1490 / P200208.51.090---
SLC9A3R19368 / O147458.4220.350.01---
FSCN16624 / Q166588.080.670.01---
OCLN100506658 / Q1662585.620---
DHRS751635 / Q9Y39481.040---
OSMR9180 / Q9965080.650---
SLC1A56510 / Q1575881.70---
RAB1B81876 / Q9H0U480.960.01---
ABCC38714 / O154387.831.090---
ZDHHC525921 / Q9C0B57.754.310.01---
PREB10113 / Q9HCU57.52.910---
PCDH95101 / Q9HC567.51.880---
CYP4F1157834 / Q9HBI67.51.170---
BASP110409 / P807237.0823.30.01---
SCARB1949 / Q8WTV071.270---
TOR1AIP126092 / Q5JTV870.70---
PDIA49601 / P1366771.080---
FAT12195 / Q1451770.340---
TMEM20984928 / Q96SK271.240---
NETO281831 / Q8NC6770.880---
ROR14919 / Q0197371.950---
RAB3511021 / Q1528671.030.01---
ACBD591452 / Q5T8D36.50.870---
GPAT384803 / Q53EU66.51.040---
UBXN423190 / Q925756.51.010---
CXADR1525 / P783106.55.540---
DARS11615 / P148686.330.90---
OSBPL8114882 / Q9BZF16.250.980.01---
TMX251075 / Q9Y32061.260---
DHCR71717 / Q9UBM760.970---
DNAJC1623341 / Q9Y2G860.660---
TMX181542 / Q9H3N161.510---
ERBB22064 / P0462662.860---
RAC15879 / P6300061.990---
RPS27L51065 / Q71UM561.180---
ARPC1B10095 / O151435.831.050.01---
SGPL18879 / O954705.51.540---
EIF2S11965 / P051985.50.970---
PDIA32923 / P301015.51.420---
RETSAT54884 / Q6NUM95.51.140---
KIRREL155243 / Q96J845.53.670---
STT3A3703 / P469775.50.940---
ARF4378 / P180855.50.990---
CLCC123155 / Q96S665.50.520---
C1orf4325912 / Q9BWL35.52.030---
SLC9A3R29351 / Q155995.5Infinity0---
TMEM201199953 / Q5SNT25.51.80---
SLC12A46560 / Q9UP955.50.840---
PRMT13276 / Q998735.50.910---
GORASP226003 / Q9H8Y85.50.730---
WWOX51741 / Q9NZC75.50.750---
SPTLC110558 / O152695.50.820---
EPB41L4B54566 / Q9H3295.179.710.01---
AP2M11173 / Q96CW150.560---
ADGRG657211 / Q86SQ450.840---
SLC33A19197 / O0040051.690---
RPN16184 / P0484350.640---
CTDSP210106 / O1459556.50---
SLC7A1123657 / Q9UPY551.210---
USP3323032 / Q8TEY750.830---
TMEM3355161 / P5708851.10---
SMPD455627 / Q9NXE450.810---
PSMC15700 / P6219150.970---
CYB5A1528 / P0016751.330---
DDX39B7919 / Q1383850.70---
YES17525 / P0794753.470---
RAB1451552 / P6110650.990---
SPINT210653 / O4329150.930---
SAR1A56681 / Q9NR3151.240---
CAMLG819 / P490694.8310.01---
PSMB55693 / P280744.50.830---
KIAA154957670 / Q9HCM34.5780---
RAB11A8766 / P624914.530---
TBL226608 / Q9Y4P34.51.20---
GPRC5C55890 / Q9NQ844.54.250---
ACBD364746 / Q9H3P74.50.940---
DCBLD2131566 / Q96PD24.51.560---
RABL3285282 / Q5HYI84.51.140---
GPAT4137964 / Q86UL34.51.170---
TMED8283578 / Q6PL244.51.490---
MET4233 / P085814.51.460---
PTGR122949 / Q149144.330.570.01---
USP3284669 / Q8NFA04.250.580.01---
HMOX23163 / P3051940.810---
SLC39A1423516 / Q1504341.790---
RCC255920 / Q9P25840.430---
ABCG29429 / Q9UNQ040.90---
ADAM98754 / Q1344340.620---
UBXN87993 / O0012440.950---
BET110282 / O1515540.920---
PGRMC210424 / O1517341.780---
LATS226524 / Q9NRM7412.240---
TOR4A54863 / Q9NXH841.180---
SNX1457231 / Q9Y5W740.680---
PIGU128869 / Q9H49041.140---
SLC35B2347734 / Q8TB6141.730---
LRP64040 / O7558140.590---
SOAT16646 / P3561040.790---
GOSR19527 / O9524940.690---
TMEM205374882 / Q6UW6841.430---
RPS66194 / P627533.830.90.01---
COPB29276 / P356063.830.430.01---
TMEM13123505 / Q925453.830.430.01---
PPIB5479 / P232843.50.940---
SLC39A1057181 / Q9ULF53.51.880---
TOR1AIP2163590 / Q8NFQ83.50.920---
KCNN43783 / O155543.51.270---
DGKE8526 / P524293.51.720---
S1PR31903 / Q995003.54.230---
ATP1A1476 / P050233.50.590---
AXL558 / P305303.51.90---
TM9SF49777 / Q925443.51.020---
STEAP355240 / Q658P33.52.250---
RPL239349 / P6282930.980---
MYADM91663 / Q96S9731.280---
AMIGO2347902 / Q86SJ230.480---
CLPTM11209 / O9600530.340---
SCD6319 / O0076730.860---
PDIA610130 / Q1508432.440---
ALG156052 / Q9BT2231.180---
TM9SF356889 / Q9HD4530.680---
WDR1857418 / Q9BV3830.980---
SMU155234 / Q2TAY730.610---
SCAMP310067 / O1482830.850---
MCAM4162 / P431213780---
RPL35A6165 / P1807730.920---
RPL18A6142 / Q025432.50.40---
RPS246229 / P628472.50.880---
SLC38A181539 / Q9H2H92.51.570---
ITGB53693 / P180842.50.130---
DDOST1650 / P396562.51.130---
ABHD211057 / P089102.50.630---
MICAL29645 / O948512.50.460---
MACO155219 / Q8N5G22.50.680---
RPL36AL6166 / Q969Q02.50.930---
SLC6A66533 / P316412.51.310---
HSD17B1151170 / Q8NBQ52.50.760---
RIC157589 / Q4ADV72.50.440---
HLA-A3105 / P044392.52.240---
SLC26A21836 / P5044321.160---
BUB39184 / O4368420.540---
TBC1D10A83874 / Q9BXI62Infinity0---
TMEM10979073 / Q9BVC622.890---
RAB2A5862 / P6101920.560---
DSTN11034 / P6098122.360---
HM1381502 / Q8TCT920.410---
GGCT79017 / O7522322.170---
SLC16A16566 / P5398520.770---
SLC29A12030 / Q9980823.590---